Inhaler

• US 5,487,378 A
• Filed: 10/04/1993
• Issued: 01/30/1996
• Est. Priority Date: 12/17/1990
• Status: Expired due to Fees

• Current Assignee: 3M Company
• Original Assignee: 3M Company
• Inventors: Emerton, Neil, Robertson, Paul A., Jensen, Borge R., Creeke, Murray A., Hodson, Peter D., Houzego, Peter J., Baum, Eric A.
• Primary Examiner(s): Lewis, Aaron J.
• Application Number:
  US08/078,151
• Time in Patent Office: 848 Days
• Field of Search: 128/200.14, 128/200.16, 128/203.12, 128/203.15, 128/203.21, 128/204.23
• US Class Current: 128/200.16
• CPC Class Codes: A61M 15/0015 located upstream of the dispenser, i.e. not traversed by the product
• CPC Class Codes: A61M 15/0018 with exhalation check valves
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 2016/0024 with an on-off output signal, e.g. from a switch
• CPC Class Codes: B05B 17/0638 spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
• CPC Class Codes: B05B 17/0661 Transducer materials
• CPC Class Codes: B05B 17/0669 Excitation frequencies
• CPC Class Codes: B05B 17/0676 Feeding means

Abstract

An inhaler for dispensing droplets of liquid medicament to a patient comprising a body having a mouthpiece or nasal adaptor and a reservoir of liquid medicament in communication with an aerosol generator. The aerosol generator includes a chamber for the liquid medicament and a nozzle arrangement having a plurality of orifices. Means are provided for cyclically pressurizing the liquid medicament in the chamber such that liquid from the chamber is periodically expelled through the orifices of the nozzle arrangement as atomizer droplets of liquid medicament. Dosage control means are also provided for deactivating the aerosol generator after a predetermined time or after a predetermined volume of liquid medicament has been expelled from the chamber.

Claims

1. An inhaler device for dispensing droplets of liquid medicament to a patient comprising a body having a mouthpiece or nasal adaptor, a reservoir of liquid medicament, and an aerosol generator in communication with said reservoir, the aerosol generator comprising a chamber for liquid medicament and a nozzle arrangement comprising a plurality of orifices in fluid flow relationship with liquid medicament in said chamber, the reservoir having walls which tend to spring to a state of maximum internal volume so as to create a slight negative head of pressure within said reservoir and said chamber, the aerosol generator further comprising means for cyclically pressurising the liquid medicament in said chamber such that liquid from said chamber is periodically expelled through the orifices as atomised droplets of liquid medicament so they may be inhaled via the mouthpiece or nasal adaptor, the inhaler device additionally comprising dosage control means for deactivating the aerosol generator after a predetermined time or after a predetermined volume of liquid medicament has been expelled from the chamber.

2. An inhaler device as claimed in claim 1 wherein the means for cyclically pressurising the liquid medicament comprises a wall opposite the nozzle arrangement comprising a flexible portion attached to a piezo-electric element such that excitation of the piezo-electric element causes vibration of the flexible portion resulting in cyclic pressurisation of the liquid medicament in the chamber.

3. An inhaler device as claimed in claim 2 comprising means to excite the piezo-electric element at a resonant frequency within the frequency range of about 10 to 500 kHz.

4. An inhaler device as claimed in claim 2 further comprising means to excite the piezo-electric element at a resonant frequency within the frequency range of about 100 to 250 kHz.

5. An inhaler device as claimed in claim 2 further comprising means to excite the piezo-electric element at a resonant frequency within the frequency range of about 50 to 250 kHz.

6. An inhaler device as claimed in claim 1 wherein the nozzle arrangement is flexible and the means for cyclically pressurising the liquid medicament comprises a piezo-electric element associated with the flexible nozzle arrangement such that excitation of the piezo-electric element causes vibration of the nozzle arrangement resulting in cyclic pressurisation of the liquid medicament in the chamber.

7. An inhaler device as claimed in claim 6 wherein the piezo-electric element is in the form off a ring secured to a metal disc, the ring and metal disc each having a central opening to accommodate attachment of the piezo-electric element to the aerosol generator adjacent the nozzle arrangement.

8. An inhaler device as claimed in claim 7 further comprising means to excite the piezo-electric element at a resonant frequency within the frequency range of about 250 to 400 kHz.

9. An inhaler device as claimed in claim 6 further comprising means to excite the piezo-electric element at a resonant frequency within the frequency range of about 250 to 400 kHz.

10. An inhaler device as claimed in claim 1 wherein the reservoir is in the form of a collapsible bag.

11. An inhaler device as claimed in claim 1 wherein the dosage control means comprises means for measuring the volume of liquid supplied to the chamber, means for generating a signal after a predetermined volume of liquid has been measured, and means for deactivating the aerosol generator upon the generation of said signal.

12. An inhaler device as claimed in claim 11 further comprising a conduit connecting the reservoir and the chamber, the volume measuring means comprising a close fitting, free moving slug positioned in said conduit and having a density matched to that of the liquid medicament and means for detecting the position of the slug comprising optical, mechanical, or electromagnetic detection means.

13. An inhaler device as claimed in claim 12 in which the volume measuring means additionally comprises two stops for limiting movement of the slug therebetween and means for setting the slug against the upstream stop.

14. An inhaler device as claimed in claim 12 wherein the detecting means comprises means for continuously detecting the position of the slug and said signal generating means is capable of providing a signal representative of the instantaneous flow rate.

15. An inhaler device as claimed in claim 14 wherein said means for cyclically pressurising the liquid medicament comprises a piezo-electric element which vibrates said aerosol generator when excited, said inhaler device further comprising means for modulating the excitation of said piezo-electric element in accordance with said signal.

16. An inhaler device as claimed in claim 1 further comprising a breath actuation sensor for detecting a patient'"'"'s inspiration through the mouthpiece or nasal adaptor and means for actuating the aerosol generator when inspiration is detected.

17. An inhaler device as claimed in claim 16 in which the breath actuation sensor comprises a pivoted vane, a flow transducer, a pressure differential transducer or a temperature sensor.

18. An inhaler device as claimed in claim 1 further comprising means for removing gas bubbles from the liquid medicament comprising a microporous material having one surface in contact with the liquid medicament and an opposite surface exposed to a region of low pressure or vacuum.

19. An inhaler device as claimed in claim 1 further comprising a venturi in communication with the mouthpiece or nasal adaptor such that the atomized droplets are directed into and substantially at right angles to the air flow generated through the venturi during inhalation through the mouthpiece or nasal adaptor.

20. An inhaler device as claimed in claim 1 wherein the inhaler device is configured as a reusable hand unit with a replaceable cartridge, said replaceable cartridge including the aerosol generator, including the nozzle arrangement and the chamber, and the reservoir as a single integral unit, a continuous passageway being formed between said reservoir and said aerosol generator so as to allow for a continuous stream of liquid medicament between said reservoir and said aerosol generator.

21. An inhaler device for dispensing droplets of liquid medicament to a patient comprising a body having a mouthpiece or nasal adaptor, a reservoir of liquid medicament, and an aerosol generator in communication with said reservoir, the aerosol generator comprising a chamber for liquid medicament and a nozzle arrangement comprising a plurality of orifices in fluid flow relationship with liquid medicament in said chamber, the aerosol generator further comprising means for cyclically pressurising the liquid medicament in said chamber such that liquid from said chamber is periodically expelled through the orifices as atomised droplets of liquid medicament so they may be inhaled via the mouthpiece or nasal adaptor, the inhaler device additionally comprising dosage control means for deactivating the aerosol generator after a predetermined time or after a predetermined volume of liquid medicament has been expelled from the chamber, the inhaler device further comprising means for removing gas bubbles from the liquid medicament comprising a microporous material having one surface in contact with the liquid medicament and an opposite surface exposed to a region of low pressure or vacuum.

22. An inhaler device as claimed in claim 21 wherein the inhaler device is configured as a reusable hand unit with a replaceable cartridge, said replaceable cartridge including the aerosol generator, including the nozzle arrangement and the chamber, and the reservoir as a single integral unit, a continuous passageway being formed between said reservoir and said aerosol generator so as to allow for a continuous stream of liquid medicament between said reservoir and said aerosol generator.

23. An inhaler device as claimed in claim 21 wherein the nozzle arrangement is flexible and the means for cyclically pressurising the liquid medicament comprises a piezo-electric element associated with the flexible nozzle arrangement such that excitation of the piezo-electric element causes vibration of the nozzle arrangement resulting in cyclic pressurisation of the liquid medicament in the chamber.

24. An inhaler device as claimed in claim 23 wherein the piezo-electric element is in the form of a ring secured to a metal disc, the ring and metal disc each having a central opening to accommodate attachment of the piezo-electric element to the aerosol generator adjacent the nozzle arrangement.