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Kinematic assay of plasma glucose concentration without blood sampling

  • US 5,487,384 A
  • Filed: 07/08/1994
  • Issued: 01/30/1996
  • Est. Priority Date: 02/25/1993
  • Status: Expired due to Term
First Claim
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1. A method for the determination of an in vivo glucose concentration without blood sampling comprising the steps of:

  • (a) directing a beam of light to a body part of a patient;

    (b) administering a hypoglycemic drug to the patient to impose a kinematic perturbation in the in vivo glucose concentration;

    (c) identifying an optical absorption band of in vivo glucose measuring an intensity of a glucose signal;

    (d) measuring a rate of decrease of the intensity of the glucose signal with time;

    (e) determining an original glucose signal from the rate of decrease measured and(f) converting the original signal into an original in glucose concentration.

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