Automated programmable stimulating device to optimize pacing parameters and method

• US 5,487,752 A
• Filed: 11/15/1994
• Issued: 01/30/1996
• Est. Priority Date: 11/15/1994
• Status: Expired due to Term

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Tockman, Bruce A., Spinelli, Julio C., Salo, Rodney W.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US08/339,567
• Time in Patent Office: 441 Days
• Field of Search: 607/18, 607/21, 607/22, 607/23, 607/24, 607/27, 607/17
• US Class Current: 607/17
• CPC Class Codes: A61N 1/3625 External stimulators
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

A method and apparatus for automatically optimizing a cardiac performance parameter of the heart, such as its cardiac output mean arterial pressure pO₂ or pCO₂. The performance parameter is optimized by periodically pacing the heart for a short period of time with stimulating pulses having a modified pacing parameter value. The intrinsic operation of the heart is monitored a majority of the time and establishes a baseline value for the cardiac performance parameter. The heart is then paced with the modified pacing parameter value during an interval that is approximately a 1:4 ratio with respect to the baseline monitoring interval. The method of the present invention can be achieved using a totally implanted pacemaker, an implanted pulse generator in combination with external equipment communicating with the pacemaker via telemetry, or by using equipment located external the patient.

Claims

1. A cardiac stimulator system comprising:

(a) a cardiac stimulator for normally applying cardiac stimulating pulses having programmable pacing cycle parameters to a heart during a first predetermined time interval sufficiently long to establish a baseline condition for a cardiac performance parameter;

(b) means for measuring and storing values of said cardiac performance parameter;

(c) means for periodically changing one of said programmable pacing cycle parameters during a second predetermined time interval that is only a small fraction of said first predetermined time interval;

(d) means including said means for measuring and storing values of said cardiac performance parameter for measuring and storing values of said cardiac performance parameters during successive ones of said first and second predetermined time intervals; and

(e) means for determining whether an improvement in said cardiac performance parameter over the baseline condition occurs during ones of said second predetermined time intervals.

2. The cardiac stimulator system as in claim 1 and further including:

(a) means for setting said programmable pacing parameter to a value corresponding to that determined to afford the maximum improvement in said cardiac performance parameter over the baseline condition.

3. The cardiac stimulator system as in claim 1, wherein said cardiac performance parameter is cardiac output.

4. The cardiac stimulator system as in claim 1 wherein said cardiac performance parameter is mean arterial pressure.

5. The cardiac stimulator system as in claim 1 wherein said cardiac performance parameter is one of pCO₂ and pO₂.

6. The cardiac stimulator system as in claim 1, wherein said programmable pacing parameter is an A-V interval between the occurrence of a paced or intrinsic P-wave and the application of one of said cardiac stimulating pulses to the heart.

7. The cardiac stimulator system as in claim 1 wherein said programmable pacing parameter is any one of pacing pulse width, pacing pulse rate, pacing pulse amplitude, atrial pacing interval and ventricular pacing interval.

8. The cardiac stimulator system as in claim 1, wherein said device is adapted to be totally implanted within a patient.

9. The cardiac stimulator system as in claim 1, wherein said cardiac stimulator is totally implantable and said means for measuring and storing and said determining means are external to the patient.

10. The cardiac stimulator system as in claim 9 and further including telemetry means in said cardiac stimulator and said means for measuring and storing for permitting two-way communication there between.

11. The cardiac stimulator system as in claim 1, wherein said cardiac stimulator, said means for measuring and storing, said means for periodically changing one of said programmable pacing cycle parameters, and said determining means are external to a patient.

12. A method of optimizing a cardiac performance parameter of a heart, comprising the steps of:

monitoring an intrinsic baseline cardiac pacing cycle parameter of a cardiac stimulator device for a first time period;

modifying said cardiac pacing cycle parameter by applying stimulating pulses to the heart for a second time period, said second time period being substantially shorter than said first time period;

comparing a cardiac performance parameter of the heart during both said first time period and said second time period, and generating an output indicative of said comparison; and

adjusting said baseline cardiac pacing cycle parameter as a function of said output.

13. The method as specified in claim 12 wherein the step of modifying said cardiac pacing cycle parameter comprises modifying an A-V interval of said cardiac stimulator device during said second time period.

14. The method as specified in claim 12 wherein the step of modifying said cardiac pacing cycle parameter comprises modifying any one of pacing pulse width, pacing pulse-rate, pacing pulse amplitude, atrial pacing interval and ventricular pacing interval.

15. The method as specified in claim 12 wherein said cardiac performance parameter comprises cardiac output of the heart, and further including the step of adjusting an A-V interval of the cardiac stimulator device as a function of compared cardiac output values.

16. The method as in claim 12 wherein said cardiac performance parameter comprises any one of pCO₂ and pO₂, and further including the step of adjusting any one of the cardiac stimulator device'"'"'s pacing pulse rate, pacing pulse width, pacing pulse amplitude, atrial pacing interval and ventricular pacing interval as a function of compared pCO₂ and pO₂ values.

17. The method as specified in claim 12 and further comprising the step of using a cardiac stimulator device implanted in the patient to automatically perform the steps recited, and pacing said heart with the adjusted baseline cardiac pacing cycle parameter if a corresponding cardiac performance parameter improves.

18. The method as specified in claim 12 further comprising the step of providing an external programmer to manually control the implanted cardiac stimulator device.