Please download the dossier by clicking on the dossier button x
×

Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms

  • US 5,489,677 A
  • Filed: 03/31/1993
  • Issued: 02/06/1996
  • Est. Priority Date: 07/27/1990
  • Status: Expired due to Term
First Claim
Patent Images

1. A compound having structure:

  • ##STR8## wherein;

    L1 -L2 -L3 -L4 is CH2 --O--NR--CH2, CH2 --NR--O--CH2, O--NR--CH2 --CH2, CH2 --CH2 --NR--O, CH2 --CH2 --O--NR, or NR--O--CH2 --CH2 ;

    R is H, alkyl having 1 to about 10 carbon atoms, alkenyl having 2 to about 10 carbon atoms, or alkynyl having 2 to about 10 carbon atoms;

    Bx is a nucleosidic base;

    Q is O, S, CH2, CHF or CF2 ;

    n is 1-50;

    X is H, OH, alkyl, F, Cl, Br, CN, CF3, OCF3, OCN, O-alkyl, S-alkyl, N-alkyl, O-alkenyl, S-alkenyl, N-alkenyl, SOCH3, SO2 CH3, ONO2, NO2, N3, NH2, aminoalkylamino, polyalkylamino or substituted silyl, wherein each said alkyl has from 1 to about 10 carbon atoms and each said alkenyl has from 2 to about 10 carbon atoms.

View all claims
  • 2 Assignments
Timeline View
Assignment View
    ×
    ×