Photolabile nucleoside and peptide protecting groups
First Claim
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1. A compound comprising the following structure:
- ##STR25## wherein Y is the C-5'"'"' oxygen group of a deoxyribonucleic acid; and
R3 is alkyl.
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Abstract
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
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Citations
35 Claims
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1. A compound comprising the following structure:
- ##STR25## wherein Y is the C-5'"'"' oxygen group of a deoxyribonucleic acid; and
R3 is alkyl. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
- ##STR25## wherein Y is the C-5'"'"' oxygen group of a deoxyribonucleic acid; and
Specification