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Tangential flow filtration process and apparatus

  • US 5,490,937 A
  • Filed: 07/06/1994
  • Issued: 02/13/1996
  • Est. Priority Date: 09/17/1990
  • Status: Expired due to Term
First Claim
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1. A process for separating species of interest having a molecular weight of about 1 to 1000 kDa from a mixture, which process comprises filtering the mixture by tangential-flow filtration through a filtration membrane having a pore size that separates said species of interest from the mixture, while maintaining flux at a level ranging from about 5 to 100% of transition point flux in the pressure-dependent region of the flux versus TMP curve, whereby the species of interest are selectively separated from the mixture, and wherein transmembrane pressure decreases or remains approximately constant as the filtration progresses.

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