Photodetecting apparatus having intensity tuneable light irradiating unit

• US 5,491,329 A
• Filed: 12/02/1994
• Issued: 02/13/1996
• Est. Priority Date: 12/03/1993
• Status: Expired due to Term

• Current Assignee: Hamamatsu Photonics KK
• Original Assignee: Hamamatsu Photonics KK
• Inventors: Tsuchiya, Yutaka, Urakami, Tsuneyuki
• Primary Examiner(s): Westin, Edward P.
• Assistant Examiner(s): LE, QUE TAN
• Application Number:
  US08/353,358
• Time in Patent Office: 438 Days
• Field of Search: 250/205, 250/204, 250/574, 250/576, 250/214 C, 250/341.1, 250/339.07, 250/339.08, 250/358.1, 356/323, 356/336, 356/442, 128/664, 128/633, 128/665
• US Class Current: 250/205
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: G01N 21/49 within a body or fluid

Abstract

Light the intensity of which is modulated to the initial intensity by a modulating signal having an ac component with a predetermined frequency and which is from the intensity tuneable light irradiating unit irradiates the scattering and absorption medium which is an object to be measured. The modulated light incident on the scattering and absorption medium propagates in the scattering and absorption medium, emerges therefrom and is incident to the photodetecting unit, and the photodetecting unit converts the incident light into an electric signal corresponding to the intensity of the incident light, and thereafter, outputs the electric signal as an optically detected signal. The feedback unit extracts the ac component from the input optically detected signal, and the intensity of the ac electric signal and the adjusting value are compared and the variation of the quantity of generating light is sent to the intensity tuneable light irradiating unit. Then, the phase difference detection is performed as the gain of the photodetecting means is fixed and the intensity of the ac component having a modulation frequency emitted from the photodetecting means is maintained so as to substantially match with the preset adjusting value.

Claims

1. A photodetecting apparatus comprising:

intensity tuneable light irradiating means for generating light to irradiate a scattering and absorption medium, an intensity of said light being modulated by a modulating signal having an ac component with a predetermined frequency, an amount of modulation of generating light or a quantity of generating light being adjustable in accordance with an external instruction;

photodetecting means for detecting an optical signal having a component with said predetermined frequency emerging from said scattering and absorption medium after said optical signal is generated from said intensity tuneable light irradiating means, irradiates said scattering and absorption medium and propagates in said scattering and absorption medium;

feedback means for receiving an optically detected signal corresponding to the intensity of said optical signal emitted from said photodetecting means, sending an instruction to said intensity tuneable light irradiating means to increase the quantity of generating light or to increase the amount of modulation of generating light when the intensity of an ac component of said optically detected signal detected by said photodetecting means is smaller than a predetermined value, and sending an instruction to said intensity tuneable light irradiating means to decrease the quantity of generating light or to decrease the amount of modulation of generating light when the intensity of the ac component of said optically detected signal detected by said photodetecting means is larger than the predetermined value; and

processing means for receiving said modulating signal and said optically detected signal and obtaining one of a timing difference between said modulating signal and said optically detected signal, and a phase difference between said modulating signal and said optically detected signal.

2. An photodetecting apparatus according to claim 1, wherein said modulating signal is formed by superimposing one or more kinds of frequency components on a dc component.

3. An photodetecting apparatus according to claim 1, wherein light generated from said intensity tuneable light irradiating means is pulsed light.

4. An photodetecting apparatus according to claim 1, wherein said intensity tuneable light irradiating means comprises

a modulating signal generating unit for generating said modulating signal on which said ac component with said predetermined frequency is superimposed;

light source means for receiving said modulating signal, and generating light the intensity of which is modulated by said predetermined frequency; and

a light transmittivity varying unit for varying light transmittivity in accordance with a quantity-of-irradiation-light indicating signal sent from said feedback means.

5. A photodetecting apparatus according to claim 1, wherein said intensity tuneable light irradiating means comprises

a modulating signal generating unit for generating said modulating signal on which said ac component with said predetermined frequency is superimposed and which has an amplitude corresponding to a quantity-of-irradiation-light indicating signal sent from said feedback means;

and

light source means for receiving said modulating signal and generating light the intensity of which is modulated by said predetermined frequency.

6. A photodetecting apparatus according to claim 4, wherein said light source means comprises a light emitting unit for generating light having a variable wavelength.

7. A photodetecting apparatus according to claim 4, wherein said light source means comprises

a plurality of light emitting units, each generating light having a different wavelength;

and

a light selecting unit for selecting and taking out one of lights generated from said plurality of said light emitting units.

8. A photodetecting apparatus according to claim 4, wherein said light source means comprises a plurality of light emitting units, each generating light having a different wavelength, and a coupling unit for coupling a plurality of lights generated from said plurality of said light emitting units;

and

said photodetecting means comprises a light selecting unit for receiving light emerging from said scattering and absorption medium, selecting and emitting light having a predetermined wavelength, and a photodetecting unit for detecting light emitted from said light selecting unit.

9. A photodetecting apparatus according to claim 1, wherein said processing means comprises

a reference signal generating unit for generating a reference signal having a reference frequency different from said predetermined frequency,

a first signal converter for receiving said reference signal and said modulating signal, calculating a product of both signals, and thereafter generating a signal having a frequency difference between said reference frequency and said predetermined frequency and including phase information of said modulating signal against said reference signal, and

a second signal converter for receiving said reference signal and said optically detected signal, calculating a product of both signals, and thereafter generating a signal having a frequency difference between said reference frequency and said predetermined frequency and including phase information of said modulating signal against said reference signal;

and

said processing means obtains one of the timing difference between said modulating signal and said optically detected signal, and the phase difference between said modulating signal and said optically detected signal, based on a waveform of the output signal of said first signal converter and a waveform of the output signal of said second signal converter.

10. A photodetecting apparatus comprising:

intensity tuneable light irradiating means for generating a first number of lights each having a different predetermined wavelength to irradiate a scattering and absorption medium, an intensity of each said light being modulated by a modulating signal having an ac component with a predetermined frequency, an amount of modulation of generating light or a quantity of generating light being adjustable in accordance with an external instruction;

light branching means for receiving optical signals each having said predetermined frequency component emerging from said scattering and absorption medium after said optical signals are generated from said intensity tuneable light irradiating means, irradiate said scattering and absorption medium and propagate in said scattering and absorption medium, and branching said optical signals into said first number of lights each having said predetermined wavelength;

photodetecting means comprising said first number of photodetecting units arranged for each said light having said predetermined wavelength, for detecting light emitted from said light branching means;

feedback means for receiving an optically detected signal for each said predetermined wavelength corresponding to the intensity of said optical signal for each said predetermined wavelength emitted from said photodetecting means, sending an instruction to said intensity tuneable light irradiating means to increase the quantity of generating light having the respective wavelength or to increase the amount of modulation of generating light having the respective wavelength when the intensity of an ac component of said optically detected signal detected by said photodetecting means is smaller than a predetermined value, and sending an instruction to said intensity tuneable light irradiating means to decrease the quantity of generating light having the respective wavelength or to decrease the amount of modulation of generating light having the respective wavelength when the intensity of the ac component of said optically detected signal detected by said photodetecting means is larger than the predetermined value; and

processing means for receiving said modulating signal and said optically detected signals and obtaining one of a timing difference between said modulating signal and said optically detected signal, and a phase difference between said modulating signal and said optically detected signal, for each said predetermined wavelength.

11. A photodetecting apparatus according to claim 10, wherein said modulating signal is formed by superimposing one or more kinds of frequency components on a dc component.

12. An photodetecting apparatus according to claim 10, wherein light generated from said intensity tuneable light irradiating means is pulsed light.

13. An photodetecting apparatus according to claim 10, wherein said intensity tuneable light irradiating means comprises

a modulating signal generating unit for generating said modulating signal on which said ac component with said predetermined frequency is superimposed;

said first number of light source means for receiving said modulating signal and generating lights, each having said different predetermined frequency, the intensity of each said light is modulated by said predetermined frequency; and

said first number of light transmittivity varying units for varying light transmittivity for each said predetermined wavelength in accordance with a quantity-of-irradiation-light indicating signal sent from said feedback means for each said predetermined wavelength.

14. A photodetecting apparatus according to claim 10, wherein said intensity tuneable light irradiating means comprises

said first number of modulating signal generating units for generating said modulating signal for each said predetermined wavelength, said ac component with said predetermined frequency being superimposed on said modulating signal, said modulating signal having an amplitude corresponding to a quantity-of-irradiation-light indicating signal sent from said feedback means for each said predetermined wavelength;

and

said first number of light source means for receiving said modulating signal and generating light having said predetermined wavelength, the intensity of said light being modulated by said predetermined frequency.

15. A photodetecting apparatus according to claim 13, wherein said light source means comprises a light emitting unit for generating light having a variable wavelength.

16. A photodetecting apparatus according to claim 13, wherein said light source means comprises

a plurality of light emitting units, each generating light having a different wavelength;

and

a light selecting unit for selecting and taking out one of lights generated from said plurality of said light emitting units.

17. A photodetecting apparatus according to claim 13, wherein said light source means comprises a plurality of light emitting units, each generating light having a different wavelength, and a coupling unit for coupling a plurality of lights generated from said plurality of light emitting units;

and

said photodetecting means comprises a light selecting unit for receiving light emerging from said scattering and absorption medium, selecting and emitting light having a predetermined wavelength, and a photodetecting unit for detecting light emitted from said light selecting unit.

18. A photodetecting apparatus according to claim 10, wherein said processing means comprises

a reference signal generating unit for generating a reference signal having a reference frequency different from said predetermined frequency,

said first number of first signal converters for receiving said reference signal and said modulating signal for each said predetermined wavelength, calculating a product of said reference signal and said modulating signal for each said predetermined wavelength, and thereafter generating a signal having a frequency difference between said reference frequency and said predetermined frequency for each said predetermined wavelength, and

a second signal converter for receiving said reference signal and said optically detected signal for each said predetermined wavelength, calculating a product of said reference signal and said modulating signal for each Said predetermined wavelength, and thereafter generating a signal having a frequency difference between said reference frequency and said predetermined frequency for each said predetermined wavelength;

and

said processing means obtains one of the timing difference between said modulating signal and said optically detected signal, and the phase difference between said modulating signal and said optically detected signal, for each said predetermined wavelength, based on a waveform of the output signal of said first signal converter and a waveform of the output signal of said second signal converter.