Magnetic resonance guided hyperthermia

• US 5,492,122 A
• Filed: 04/15/1994
• Issued: 02/20/1996
• Est. Priority Date: 04/15/1994
• Status: Expired due to Fees

• Current Assignee: Grumman Aerospace Corporation (Northrop Grumman Corporation), The Research Foundation for The State University of New York (State University of New York)
• Original Assignee: Northrop Grumman Corporation
• Inventors: Spacht, Glenn, Barbour, Susan, Crugnale, Eric, Button, Terry, McGill, Robert E., Cermignani, Justine D.
• Primary Examiner(s): ZELE, KRISTA MICHELLE
• Application Number:
  US08/228,348
• Time in Patent Office: 676 Days
• Field of Search: 128/653.2, 128/653.5, 128/736, 607/96, 607/101, 607/102, 607/154, 607/156, 324/309, 324/315, 324/318, 324/322
• US Class Current: 600/411
• CPC Class Codes: A61N 1/403 for thermotherapy, e.g. hyperthermia
• CPC Class Codes: A61N 5/02 using microwaves
• CPC Class Codes: G01R 33/4804 Spatially selective measurement of temperature or pH

Abstract

A hyperthermia treatment apparatus includes an annular radio frequency (RF) antenna array with bolus that is compatible with a magnetic resonance imaging (MRI) machine. Antenna elements polarized parallel to the axis of the cylinder are used for forming a Specific Absorption Ratio (SAR) map as well as for directing the energy to accomplish hyperthermia. The array may be dynamically controlled to focus energy at any specified region within the cylinder. The array is positioned inside an MRI machine and is tuned to the machine'"'"'s hydrogen resonant frequency. For treatment planning, the array is employed to form an SAR map via RF current density imaging. Using this map, array phase, amplitude, and temporal weighting are optimized until the SAR maxima is congruent with the treatment volume. For treatment, RF radiation is applied to the subject to induce heating of the treatment volume using these optimal array parameters. Temperature is periodically determined via noninvasive MRI methods (i.e., diffusion imaging, T₁ map, etc.) in order to obtain an image that includes isotherms from which the pattern of heating can be observed. Feedback is provided such that adjustment may be made to compensate for bioheat transfer.

Claims

1. A system for hyperthermia treatment comprising:

an MR imaging machine having a proton MR imaging frequency for generating an MR image of a patient;

means including an RF phased antenna array positioned within the MR imaging machine for directing radio frequency (RF) radiation, at a frequency substantially equal to the proton MRI frequency, to a pathology in the patient situated within the MRI machine in order to non-invasively generate a specific absorption ratio (SAR) map of the patient for use in optimizing a subsequent application of RF power by the array during a hyperthermia treatment;

means including processors and controllers for controlling the RF phased array in concert with the MR imaging machine to provide the hyperthermia treatment;

means for noninvasively monitoring a temperature of said tumor and surrounding tissues upon evaluation of the tumor temperature in response to exposure to said radiation during the hyperthermia treatment;

and

means for dynamically controlling the RF power delivered to the target treatment area during the treatment based on said temperature monitoring means and said SAR map.

2. Apparatus as claimed in claim 1, wherein said temperature monitoring means comprises means for forming a rapid diffusion image of a patient using the MRI machine.

3. Apparatus as claimed in claim 1, wherein said RF phased array comprises a plurality of antenna elements.

4. Apparatus as claimed in claim 3, further comprising means for individually adjusting a phase and amplitude of each of said antenna elements.

5. Apparatus as claimed in claim 4, further comprising means for forming a visual display of said SAR map of radiation emitted by said antenna elements for comparison with said MR image of the patient in order to predict adjustments of the antenna elements which will provide for optimum coverage of the tumor.

7. Apparatus as claimed in claim 3, wherein said antenna elements are polarized parallel to a cylinder axis of the MRI machine.

8. Apparatus as claimed in claim 1, further comprising means for supplying a temporally averaged energy distribution of said radiation to improve localization in tumor.

6. Apparatus as claimed in 5, further comprising means for determining the optimum operating amplitude and phase of the antenna elements to provide for optimum coverage of the tumor.

9. Apparatus for hyperthermia treatment, comprising:

an MRI machine having an MR imaging resonant frequency for generating an MR image of a patient;

means including an RF phased array including a plurality of individually adjustable antenna elements positioned within the MRI machine for directing RF radiation having a frequency substantially equal to the resonant frequency at a tumor within the patient situated within the MRI machine;

means for supplying a temporally averaged energy distribution to said patient to improve localization of the tumor during a hyperthermia treatment; and

means for determining and forming a visual display of an specific absorption ratio (SAR) distribution of radiation emitted by said antenna elements prior to the hyperthermia treatment for comparison with the MR image of the patient in order to predict adjustments of the antenna elements which will provide for optimum coverage of the tumor and thereby predict said temporally averaged energy distribution during the hyperthermia treatment.

10. Apparatus as claimed in claim 9, wherein said antenna elements are polarized parallel to a cylinder axis of the MRI machine.

11. Apparatus for hyperthermia treatment, comprising:

an MRI machine having an MR imaging resonant frequency for generating an MR image of a patient;

means including an RF phased array including a plurality of individually adjustable antenna elements positioned within the MRI machine for directing RF radiation having a frequency substantially equal to the resonant frequency at a tumor within the patient situated within the MRI machine; and

means for determining and forming a visual display of an specific absorption ratio (SAR) distribution of radiation emitted by said antenna elements for comparison with the MR image of the patient in order to predict adjustments of the antenna elements which will provide for maximum coverage of the tumor during a subsequent hyperthermia treatment, said SAR distribution being obtained by measuring current distributions resulting from emission of said radiation by said antenna elements prior to the treatment.

12. Apparatus as claimed in claim 11, wherein said antenna elements are polarized parallel to a cylinder axis of the MRI machine.

13. A method of treatment, comprising the steps of:

placing a patient in a MRI machine including bolus/treatment array and taking a conventional MRI image;

using an RF phased array in said bolus/treatment array to generate a specific absorption ratio (SAR) map image to permit obtaining appropriate phase, amplitude, and temporal averaging; and

superimposing the conventional and SAR map images and adjusting the phase and amplitude settings if necessary to obtain congruence between the images; and

subsequently applying RF radiation from the phased array to heat the tumor.

14. A method as claimed in claim 13, wherein the step of applying RF radiation comprises the step of applying energy which is temporally averaged to improve localization in tumor.

15. A method as claimed in claim 14, wherein the step of applying the RF radiation comprises the step of keeping the tumor at approximately 42°

-43°

C. for 30-60 minutes.

16. A method as claimed in claim 13, further comprising the step of, periodically during the step of applying RF radiation for heating, obtaining a rapid diffusion image in order to monitor temperatures of said tumor and surrounding tissues.

17. A method of hyperthermia treatment, comprising the steps of:

placing a patient in a bolus/treatment array situated in an MRI machine;

applying RF energy to the patient and measuring resulting current densities in order to generate an specific absorption ratio (SAR) map of the patient;

using the SAR map as a basis for temporally averaging radiation to be applied to the patient during a hyperthermia treatment; and

providing the hyperthermia treatment by applying the temporally averaged RF radiation to the patient in order to heat a tumor in the patient to a predetermined temperature for a predetermined period of time.

18. A method as claimed in claim 17, further comprising the step of, periodically, during the step of applying RF radiation by heating, obtaining a rapid diffusion image in order to monitor temperatures of said tumor and surrounding tissues.

19. A method as claimed in claim 17, wherein the step of applying the RF radiation comprises the step of keeping the tumor at approximately 42°

-43°

C. for 30-60 minutes.