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Antipsychotic composition and method of treatment

  • US 5,492,907 A
  • Filed: 12/09/1992
  • Issued: 02/20/1996
  • Est. Priority Date: 12/09/1992
  • Status: Expired due to Term
First Claim
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1. A method for treating schizophrenia and schizoaffective illnesses comprising the step of administering to a patient in need of such treatment a therapeutically effective amount of a combination of (i) an α

  • 2 -adrenergic receptor antagonist, and (ii) a D2 dopamine receptor antagonist in a pharmaceutically acceptable carrier,wherein said α

    2 -adrenergic receptor antagonist (i) is one or more selected from the group consisting of idazoxan, yohimbine, ethoxy-idazoxan, fluperoxan and atipamezole, andwherein said D2 dopamine receptor antagonist (ii) is one or more antipsychotic neuroleptic drugs selected from the group consisting of thiopropazate, chlorpromazine, triflupromazine, mesoridazine, pipercetazine, thioridazine, acetophenazine, fluphenazine, perphenazine, trifluoperazine, chlorprothixene, thiothixene, haloperidol, butaperazine, prochlorperazine, carphenazine, bromperidol, loxapine, and molindone.

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