Apparatus and method for measuring cardiac output
First Claim
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1. A method of measuring cardiac output in a body'"'"'s circulation, comprising the steps of:
- a) injecting a defined amount (Mo) of an indicator dye into the body'"'"'s circulation to establish an indicator dye concentration time course therein, said dye concentration time course having a distribution phase and an elimination phase;
b) directing light non-invasively into the body at a chosen site;
c) non-invasively detecting light transmitted through or reflected from the body at two wavelengths and determining its intensity;
d) measuring the indicator dye concentration from the detected light intensity;
e) determining the concentration time course (cind (t)) of the indicator dye;
f) utilizing a reference dye having a known concentration in the circulation to determine the concentration time course of the indicator dye relative to the reference dye;
g) measuring the concentration time course of the indicator dye over a period which permits the indicator dye distribution phase and elimination phase to be assessed by mathematical modeling of the measured concentration time course;
h) using additional information regarding recirculation and elimination of the indicator dye to calculate cardiac output from dye curves with slow onset and slow downslope due to low perfusion at the site; and
i) calculating the cardiac output from the amount of indicator dye injected (Mo) and from the indicator dye concentration time course (cind (t)) using the formula ##EQU2##
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Abstract
An apparatus and method for measuring cardiac output in a patient, The sensed pulsatile component of light at at least two wavelengths transmitted through or reflected from a site on the patient is measured. The measurements are used to calculate the relative concentration of an indicator dye relative to a reference dye, the concentration of the latter being known. Calibrated absolute concentration time curves are then calculated for the indicator dye.
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Citations
3 Claims
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1. A method of measuring cardiac output in a body'"'"'s circulation, comprising the steps of:
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a) injecting a defined amount (Mo) of an indicator dye into the body'"'"'s circulation to establish an indicator dye concentration time course therein, said dye concentration time course having a distribution phase and an elimination phase; b) directing light non-invasively into the body at a chosen site; c) non-invasively detecting light transmitted through or reflected from the body at two wavelengths and determining its intensity; d) measuring the indicator dye concentration from the detected light intensity; e) determining the concentration time course (cind (t)) of the indicator dye; f) utilizing a reference dye having a known concentration in the circulation to determine the concentration time course of the indicator dye relative to the reference dye; g) measuring the concentration time course of the indicator dye over a period which permits the indicator dye distribution phase and elimination phase to be assessed by mathematical modeling of the measured concentration time course; h) using additional information regarding recirculation and elimination of the indicator dye to calculate cardiac output from dye curves with slow onset and slow downslope due to low perfusion at the site; and i) calculating the cardiac output from the amount of indicator dye injected (Mo) and from the indicator dye concentration time course (cind (t)) using the formula ##EQU2##
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2. A method of measuring cardiac output in the circulation of a human body, comprising the steps of:
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a) injecting a defined amount (Mo) of an indicator dye into the body'"'"'s circulation to establish an indicator dye concentration time course therein; b) directing light non-invasively into the body at a chosen site; c) non-invasively detecting light transmitted through or reflected from the body at two wavelengths and determining its intensity; d) measuring the indicator dye concentration from the detected light intensity; e) utilizing a reference dye having a known concentration in the circulation to determine the concentration time course of the indicator dye relative to the reference dye; f) using the pulsatile components of the light intensities (Iind pulse (t)) and Iref pulse (t)) to compute a derived parameter (M(t), where M(t)=fm (Iind pulse (t), Iref pulse (t)) with fm being the ratio of Iind pulse (t) and Iref pulse (t), M(t) being related to the ratio of the indicator dye to the reference dye (cind/ref (t)) by a calibration function (cind/ref (t)=fcal (M(t)); g) deriving an absolute concentration time course (cind (t) of the indicator dye required for the calculation of cardiac output from (cind/ref (t) and a known intravascular concentration of the reference dye (cref) (cind (t)=fref (cind/ref (t), cref); and h) calculating the cardiac output from the amount of indicator dye injected (Mo) and from the absolute indicator dye concentration time course (cind (t)) using the formula ##EQU3##
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3. A method of measuring cardiac output in a body'"'"'s circulation comprising the steps of:
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a) injecting a defined amount (Mo) of an indicator dye into the body'"'"'s circulation to establish an indicator dye concentration time course therein; b) directing light non-invasively into the body at a chosen site; c) non-invasively detecting light transmitted through or reflected from the body at two wavelengths and determining its intensity; d) determining the indicator dye concentration from the detected light intensity; e) using pulsatile components of the light intensities at the two wavelengths to compute a derived parameter (M(t), M(t) being related to the amount of indicator dye by a calibration function; f) using (t) deriving an absolute concentration time course (cind (t) of the indicator dye required for the calculation of cardiac output; and g) calculating the cardiac output from the amount of indicator dye injected (Mo) and from the absolute indicator dye concentration time course (cind (t)) using the formula ##EQU4##
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Specification