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Fiber optic evanscent wave sensor for immunoassay

  • US 5,494,798 A
  • Filed: 12/09/1993
  • Issued: 02/27/1996
  • Est. Priority Date: 12/09/1993
  • Status: Expired due to Fees
First Claim
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1. A fiber optic sensor for immunoassay comprising:

  • a fiber optic coupler having a plurality of input optical fibers each having a core;

    said cores being coupled for exchange of optical signals in a waist region;

    a plurality of output optical fibers emerging from said waist region;

    said fiber optic coupler distributing an input optical signal incident to one of said input optical fibers between said plurality of output optical fibers;

    a first immunoreactant coated on said waist region, wherein said first immunoreactant is capable of specifically binding to a target analyte and wherein said first immunoreactant is an antibody or an antigen;

    means for inserting light into at least one of said input optical fibers, whereby an evanescent region is produced surrounding said waist region;

    means for measuring light magnitude emitted from a plurality of said output optical fibers; and

    means for comparing the magnitude of light emitted at least two of said output optical fibers.

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