Method of correcting componential concentration in expiration and expiration analyzer

• US 5,495,744 A
• Filed: 10/24/1994
• Issued: 03/05/1996
• Est. Priority Date: 10/25/1993
• Status: Expired due to Term

• Current Assignee: Kyoto Daiichi Kagaku Company Limited
• Original Assignee: Kyoto Daiichi Kagaku Company Limited
• Inventors: Hiromoto, Mitsuo, Gang, Meng, Ueda, Hideo, Yamasaki, Yutaka
• Primary Examiner(s): Williams, Hezron E.
• Assistant Examiner(s): LARKIN, DANIEL SEAN
• Application Number:
  US08/327,909
• Time in Patent Office: 498 Days
• Field of Search: 73/1 G, 73/23.3, 128/719, 128/730, 422/84, 436/900
• US Class Current: 73/1.07
• CPC Class Codes: A61B 5/083 Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
• CPC Class Codes: Y10S 436/90 Breath testing

Abstract

A first sample measuring passage provided between a collection port and a suction pump has a sample gas measurer for measuring expiration components, while a second sample measuring passage which is provided in parallel with the first sample measuring passage has a standard gas measurer for measuring O₂ gas. Assuming that [A] represents a measured value of a target component in an expiration sample and [b₁ ] represents O₂ concentration in the expiration sample, correction is made on the basis of:

[M]=f.sub.1 ·(21-[a.sub.1 ]) [A]/(21-[b.sub.1 ])

where [M] represents the corrected measured value of the target component, [a₁ ] represents O₂ concentration in end-tidal air which is supplied as a constant such as 15.3, for example, and f₁ represents an experimentally prescribed coefficient such as 1.67, for example.

Claims

1. A method of correcting componential concentration in expiration, comprising the steps of:

analyzing an expiration sample of alveolar air, being mixed with at least one of air from a dead space and ambient air, for obtaining a measured value of a target component;

measuring at least one of O₂ gas concentration and CO₂ gas concentration as a standard gas concentration in said expiration sample; and

correcting said measured value of said target component by a measured value of said standard gas concentration in said expiration sample with reference to a standard gas concentration in end-tidal air.

2. A method of correcting componential concentration in expiration in accordance with claim 1, wherein

said steps of obtaining said measured value of said target component and measuring said standard gas concentration are carried out by measuring means being different from each other.

3. A method of correcting componential concentration in expiration in accordance with claim 1, wherein

said steps of obtaining said measured value of said target component and measuring said standard gas concentration are simultaneously carried out by the same measuring means.

4. A method of correcting componential concentration in expiration in accordance with claim 1, wherein

said correction is made on the basis of:

space="preserve" listing-type="equation">[M]=f.sub.1 ·

(21-[a.sub.1 ]) [A]/(21-[b.sub.1 ])

assuming that [A] represents said measured value of said target component in said expiration sample, [b₁ ] represents said O₂ concentration in said expiration sample, [M] represents corrected said measured value of said target component, [a₁ ] represents O₂ concentration in end-tidal air, being a constant, and f₁ represents an experimentally prescribed coefficient.

5. A method of correcting componential concentration in expiration in accordance with claim 1, wherein

said correction is made on the basis of:

space="preserve" listing-type="equation">[M]=f.sub.2 ·

[a.sub.2 ][A]/[b.sub.2 ]

assuming that [A] represents said measured value of said target component in said expiration sample, [b₂ ] represents said CO₂ concentration in said expiration sample, [M] represents corrected said measured value of said target component, [a₂ ] represents CO₂ concentration in end-tidal air, being a constant, and f₂ represents an experimentally prescribed coefficient.

6. An expiration analyzer comprising:

a first sample measuring passage means, having a sample gas measurer which measures at least one or two components in expiration, for receiving from a collection port an expiration sample of alveolar air being mixed with at least one of air from a dead space and ambient air;

a second sample measuring passage means, having a standard gas measurer which measures at least one of O₂ gas and CO₂ gas as standard gas and being provided in parallel with said first sample measuring passage means, for receiving from said collection port said expiration sample being identical to that guided in said first sample measuring passage means;

a heating means for heating passages between said collection port and said sample and standard gas measurers; and

a computing means for correcting a componential measured value in said expiration sample, being measured by said sample gas measurer, by a measured value of said standard gas concentration in said expiration sample, being measured by said standard gas measurer, with reference to concentration of a standard gas in end-tidal air.

7. An expiration analyzer in accordance with claim 6,

further comprising a suction pump for sucking the expiration sample into said first and second sample measuring passages through said collection port.

8. An expiration analyzer in accordance with claim 6,

further comprising a switching valve being provided on a confluent point located upstream in said first and second sample measuring passages, for switching the expiration sample to be introduced into said first and second sample measuring passages.

9. An expiration analyzer in accordance with claim 6, wherein

said computing element makes said correction on the basis of:

space="preserve" listing-type="equation">[M]=f.sub.1 ·

(21-[a.sub.1 ]) [A]/(21-[b.sub.1 ])

assuming that [A] represents said measured value of said target component in said expiration sample, [b₁ ] represents said O₂ concentration in said expiration sample, [M] represents corrected said measured value of said target component, [a₁ ] represents O₂ concentration in end-tidal air, being a constant, and f₁ represents an experimentally presecribed coefficient.

10. An expiration analyzer in accordance with claim 6, wherein

said computing element makes said correction on the basis of:

space="preserve" listing-type="equation">[M]=f.sub.2 ·

[a.sub.2 ][A]/[b.sub.2 ]

assuming that [A] represents said measured value of said target component in said expiration sample, [b₂ ] represents said CO₂ concentration in said expiration sample, [M] represents corrected said measured value of said target component, [a₂ ] represents CO₂ concentration in end-tidal air, being a constrant, and f₂ represents an experimentally prescribed coefficient.