Medication cassette for an automatic aerosol medication delivery

• US 5,497,764 A
• Filed: 03/09/1995
• Issued: 03/12/1996
• Est. Priority Date: 03/05/1991
• Status: Expired due to Term

• Current Assignee: Aradigm Corporation
• Original Assignee: Aradigm Corporation
• Inventors: Rubsamen, Reid M., Ritson, Carl
• Primary Examiner(s): Lewis, Aaron J.
• Application Number:
  US08/404,838
• Time in Patent Office: 369 Days
• Field of Search: 128/200.14, 128/200.23, 128/204.23
• US Class Current: 128/200.14
• CPC Class Codes: A61J 7/0418 with electronic history memory
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 16/0858 Pressure sampling ports
• CPC Class Codes: A61M 16/202 electrically actuated
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/60 with identification means
• CPC Class Codes: A61M 2205/6018 providing set-up signals for the apparatus configuration
• CPC Class Codes: A61M 2205/6027 Electric-conductive bridges closing detection circuits, with or without identifying elements, e.g. resistances, zener-diodes
• CPC Class Codes: A61M 2205/6036 characterised by physical shape, e.g. array of activating switches
• CPC Class Codes: A61M 2205/6045 having complementary physical shapes for indexing or registration purposes
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 2205/8212 with means or measures taken for minimising energy consumption
• CPC Class Codes: B01F 23/2132 using nozzles
• CPC Class Codes: B01F 35/714 for feeding predetermined amounts B01F35/88 takes precedence
• CPC Class Codes: B01F 35/7179 using sprayers, nozzles or jets
• CPC Class Codes: B01F 35/7547 : using valves, gates, orifices or openings
• CPC Class Codes: G01F 1/363 : with electrical or electro-mechanical indication G01F1/37 and G01F1/38 take precedence
• CPC Class Codes: G01F 1/40 : Details of construction of the flow constriction devices
• CPC Class Codes: G01F 1/50 : Correcting or compensating means
• CPC Class Codes: G01F 13/006 : measuring volume in function of time
• CPC Class Codes: G01F 15/002 : for gases

Abstract

A portable, battery powered, hand-held system for releasing a controlled dose of aerosol medication for inhalation by a patient including a durable body and a medication cassette inserted in the durable body. The cassette includes a housing for containing a canister of medication, bears an identification code, and permits the canister to be manually depressed to release a dose, e.g., a metered dose, when out of the durable body. The durable body includes an actuator mechanism for engaging an inserted cassette and its canister, and an actuator release mechanism for controlling the actuator mechanism to depress the canister for a selected period of time to release the desired dose of medication and then the release the canister. The actuator mechanism, includes a compression spring for depressing the canister and a torsion spring for reloading the compression spring. The torsion spring is reloaded by rotating the cassette from an open position for delivering aerosol to a closed position. The actuator release mechanism includes a motor and trigger pin assembly that controls the release of the compression spring and the torsion spring, and, hence, the time that the canister is depressed. The motor operates in response to sensed flow satisfying a selected delivery threshold. The durable body includes a flow sensor having an asymmetrical orifice that is calibrated, independent of the cassette, to convert the sensed pressure due to flow into a flow rate. The orifice is separately calibrated for an inhalation flow rate range and an exhalation flow rate range over a selected number of known flow rates. The sensed pressure value is corrected for transducer offset drift and converted to a flow rate using the calibration data and piecewise linear interpolation.

Claims

1. A system for treating a patient with aerosolized medication. comprising:

a hand-held device for delivering aerosolized medication comprising a body member with a receiving chamber;

a cassette, insertable into the receiving chamber of the hand-held device, the cassette comprising;

a canister having a body containing an aerosol medication and a valve stem movable in a longitudinal first axis relative to the canister body to release an amount of aerosol from the valve of the canister;

a mouthpiece having a first opening from which a patient can receive aerosolized medication, a second opening from which aerosolized medication released from the valve of the canister is received, a mouthpiece air flow path between the first and second openings, and a valve stem receptacle for receiving and securely seating the valve stem, the valve stem receptacle being located at the second opening;

a cassette housing having a cavity for receiving the canister, the cassette housing having a first opening connected to the second opening of the mouth piece, the cassette housing having a second opening, and a cassette housing air flow path between the first and second openings of the cassette housing, the cassette housing enclosing at least a portion of-the canister and having an outer configuration specifically designed for insertion into the receiving chamber of the hand-held device;

wherein the canister can reciprocate in the first axis relative to the cassette housing to release a dose of medication, and the mouthpiece air flow path and cassette housing flow paths are in open communication;

further wherein the cassette housing has an outer configuration which comprises a protrusion for use in aligning the cassette for insertion into the receiving chamber of the device and for retaining the cassette in the receiving chamber of the device.

2. The system of claim 1 wherein the cassette housing further comprises a closed top end opposite the first opening so that the canister cannot be manually moved to release an amount of aerosol.

3. The system of claim 2 wherein the aerosol medication is a narcotic.

4. The system of claim 1 wherein the cassette housing further comprises a closed top end having an aperture therein, the aperture having a dimension so that the canister is manually movable to release an amount of aerosol and is not removable from the cassette housing.

5. The system of claim 4 wherein the canister contains a blend of medication and propellant under pressure and the canister body has a concave bottom end disposed toward the housing top end aperture, further comprising a disk located between the top end and the concave canister bottom.

6. The system of claim 1 wherein the outer configuration of the cassette housing further comprises a first series of protrusions corresponding to an identification code.

7. The system of claim 6 wherein the identification code is a multi-bit code identifying the contents of the canister.

8. The system of claim 6 wherein the identification code is a multi-bit code identifying the delivery parameters for releasing a dose of the contents of the canister.

9. The system of claim 1 wherein the cassette housing further comprises a first electronic device containing an identification code.

10. The system of claim 9 wherein the identification code is a multi-bit code which code provides identification of the contents of the canister to the hand held device into which the cassette is insertable.

11. The system of claim 10 wherein the identification code is a multi-bit code which code provides information on the delivery parameters for releasing a dose of the contents of the canister.

12. The system of claim 9 wherein the identification code is a multi-bit code which code provides information on the delivery parameters for the contents of the canister.

13. The system of claim 9 wherein the first electronic device is a resistor having a resistance value as the identity code.

14. The system of claim 9 wherein the first electronic device is a memory device containing one or more digital words identifying one of the identity of the contents of the canister and the delivery parameters for releasing a dose of aerosol from the canister.

15. The system of claim 14 wherein the memory device contains a value corresponding to the initial number of dosages of medication in the canister.

16. The system of claim 14 wherein the memory device contains a value corresponding to the number of dosages of medication delivered from the canister.

17. The system of claim 9 wherein the first electronic device contains an identification of the number of dosages of medication originally in the canister.

18. The system of claim 17 wherein the first electronic device contains an identification code uniquely identifying the cassette.

19. The system of claim 9 wherein the first electronic device contains an identification code uniquely identifying the cassette.

20. The system of claim 19 wherein the first electronic device is a memory device.

21. The system of claim 20 wherein the memory device is programmable to maintain a count of the number of doses of medication remaining in the canister.

22. The system of claim 20 wherein the memory device is programmable to maintain a count of the number of doses of medication used.

23. The system of claim 1 wherein the canister further comprises product labeling and the cassette housing is made of a transparent material so that labelling on the canister is visible through the housing.