Iontophoretic structure for medical devices

• US 5,498,248 A
• Filed: 03/14/1994
• Issued: 03/12/1996
• Est. Priority Date: 11/12/1992
• Status: Expired due to Term

• Current Assignee: Bridge Blood Technologies LLC
• Original Assignee: Implemed, Inc.
• Inventors: Milder, Fredric L.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): ELGART, VANITHA M
• Application Number:
  US08/212,157
• Time in Patent Office: 729 Days
• Field of Search: 604/265, 604/280, 604/20, 604/21, 604/8, 604/266, 604/27, 604/173, 128/640, 128/642, 607/149, 607/152, 607/153, 607/122
• US Class Current: 604/265
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body

Abstract

An iontophoretic structure for medical devices is provided that uses controlled electrical current derived from two dissimilar galvanic materials to drive oligodynamic metal ions into solution to kill bacteria on and near the device to which the structure is affixed. In one embodiment, a first galvanic material separated from a second galvanic material by a resistive material produces an anti-bacterial current flow when placed in contact with an electrolytic fluid. In another embodiment, a cylindrical elastomeric catheter incorporates a first and a second galvanic material separated by a resistive material which controls a current flow between the galvanic materials when the catheter is immersed in an electrolytic fluid. The galvanic materials can be dissimilar metal powders embedded in a conductive polymer substrate that forms an iontophoretic composite material, or dissimilar metals arranged in layers separated by a resistive layer. In yet another embodiment, the iontophoretic composite material is configured as an infection control sleeve that covers a portion of an ordinary catheter or cannula. Methods of protecting implantable medical devices and body structures with the iontophoretic structures are also provided.

Claims

1. An iontophoretic structure comprising:

a first material having a first galvanic electrical potential;

a second material having a second galvanic electrical potential and a conductive polymer separating said first material from said second material, said conductive polymer having a predetermined resistivity and controlling a current flow produced between said first material and said second material when said iontophoretic structure is in contact with an electrolytic fluid.

2. The iontophoretic structure of claim 1, wherein said first material comprises silver and said second material comprises gold.

3. The iontophoretic structure of claim 1, wherein said first material comprises silver and said second material comprises platinum.

4. The iontophoretic structure of claim 1, wherein said first material comprises silver and said second material comprises copper.

5. The iontophoretic structure of claim 1, wherein said conductive polymer is chosen from the group consisting of polyvinyl, polyester, polyethylene, polyurethane, and polyvinylidene.

6. The iontophoretic structure of claim 1, wherein said first material includes a first metal powder and said second material includes a second metal powder, said first and said second metal powders embedded in said conductive polymer.

7. An iontophoresis catheter comprising:

an elastomeric cylindrical wall having an outer wall surface and an inner wall surface, said inner wall surface defining a lumen for containing a fluid, and a distal end and a proximal end, each said end having at least one opening to permit introduction or evacuation of said fluid from said lumen, said wall comprising a first material having a first galvanic electrical potential and a second material having a second galvanic electrical potential, said first and second materials separated by a conductive polymer having a predetermined resistivity for controlling a current flow produced between said first material and said second material when said iontophoresis catheter is in contact with an electrolytic fluid.

8. The iontophoresis catheter of claim 7, wherein said first material comprises silver and said second material comprises gold.

9. The iontophoresis catheter of claim 7, wherein said first material comprises silver and said second material comprises platinum.

10. The iontophoresis catheter of claim 7, wherein said first material comprises silver and said second material comprises copper.

11. The iontophoresis catheter of claim 7, wherein said conductive polymer is chosen from the group consisting of polyvinyl, polyurethane, polyester, polyethylene, and polyvinylidene.

12. The iontophoresis catheter of claim 7, wherein said first material comprises a first metal powder, said second material comprises a second metal powder, and said wall comprises said conductive polymer, said first and said second metal powder embedded in said conductive polymer, wherein said conductive polymer controls a current flow produced between said first metal powder and said second metal powder.

13. The iontophoresis catheter of claim 12, wherein said first and second metal powder, and said conductive polymer comprise a composite material extruded to form at least part of said cylindrical elastomeric wall.

14. The iontophoresis catheter of claim 12, wherein said first and second metal powder, and said conductive polymer comprise a liquified composite material into which said cylindrical elastomeric wall is dipped to form a composite coating.

15. An iontophoresis catheter comprising:

an elastomeric cylindrical wall having an outer wall surface and an inner wall surface, said inner wall surface defining a lumen for containing a fluid, and a distal end and a proximal end, each said end having at least one opening to permit introduction or evacuation of said fluid from said lumen, said elastomeric cylindrical wall comprising a first metal powder and a second metal powder embedded in a conductive polymer having a predetermined resistivity for controlling a current flow produced between said first and second metal powder when said iontophoresis catheter is contact with an electrolytic fluid.