Device for storing a liquid medicinal substance and for administering eye drops

• US 5,499,751 A
• Filed: 10/18/1993
• Issued: 03/19/1996
• Est. Priority Date: 01/21/1992
• Status: Expired due to Fees

• Current Assignee: Gabriel Meyer
• Original Assignee: Gabriel Meyer
• Inventors: Meyer, Gabriel
• Primary Examiner(s): Kashnikow, Andres
• Assistant Examiner(s): Derakshani, Philippe
• Application Number:
  US08/119,113
• Time in Patent Office: 883 Days
• Field of Search: 222/189, 222/162, 222/320, 222/321, 222/420, 222/386, 604/190, 604/218, 604/231, 604/265, 604/256, 604/301, 604/311, 604/295, 128/763
• US Class Current: 222/386
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61J 1/145 using air filters
• CPC Class Codes: A61J 1/1456 using liquid filters

Abstract

The device represented in its storage position contains essentially a body (11) in synthetic material containing a reservoir (10) containing a medicinal substance (29). The body (11) is fitted with an applicator nozzle (15). The reservoir (10) has the shape of a cylindrical glass jacket (17) closed at one end by a movable sealing plug (18) and at the other end by a mobile piston (19). The mobile piston is linked with a plunger (16) which advantageously is a spring in a synthetic material. A flow rate controlling filter (19) is lodged in the applicator nozzle (15). This device is advantageous because the reservoir can be sterilized with its contents. The filter and the piston along with the plunger guarantee the medicinal substance remains in an aseptic state by preventing contamination via the applicator nozzle.

Claims

1. A device for storing a liquid medicinal substance and administering eye drops constituted by this substance, comprising a rigid cylindrical reservoir containing said substance and a distributor being connected to one end of said reservoir while the opposite end of said cylindrical reservoir being closed, said distributor having an applicator nozzle including an orifice designed to form and administer said drops to an eye of a patient, said distributor including a flow rate controlling device comprising at least one membrane with calibrated micropores which seals said reservoir, a sliding piston being engaged within said reservoir and being controlled by said device for dispensing liquid medicinal substance from said device, and said flow rate controlling device being connected to asepticization devices having an oligodynamic action on a predetermined volume of medicinal substance situated upstream from said orifice in which the piston contains a rigid retention stop and a flexible sheath defining an internal cavity, said retention stop comprises a supporting stud, and a total height of said stop with the supporting stud is roughly equal, at rest, to a height of the internal cavity.

2. A device in accordance with claim 1, wherein said flow rate controlling device comprising at least one membrane with calibrated micropores is located at a base of said distributor.

3. A device in accordance with claim 1, in which said sliding piston is connected with a hollow rigid element connected with a capsule, said cylindrical reservoir is at least partially inserted within said capsule, and said hollow element communicates with said distributor via at least one of a filter and said asepticizing devices.

4. A device in accordance with claim 3, in which the flow rate controlling device contains a depth filter made up of a sintered material containing at least one heavy metal having an oligodynamic anti-bacterial effect, chosen from the heavy metals, compounds and mixtures of heavy metals and mixtures of these compounds.

5. A device in accordance with claim 1, in which said asepticizing devices contain at least one of silver and silver oxide.

6. A device in accordance with claim 1, in which the predetermined volume is less than a volume of one drop.

7. A device in accordance with claim 6 in which a ratio between the predetermined volume measured in microlitres and a surface area of said asepticizing devices measured in square millimetres is less than 1.

8. A device in accordance with claim 1, in which said piston is provided with elastic devices arranged to absorb residual pressure.

9. A device in accordance with claim 8, in which said elastic devices contain a less resistant area installed on a piston side in contact with the medicinal substance and arranged to change shape under thrust exerted on said piston and to return to a normal state after conclusion of the thrust.