Biodegradable drug delivery vascular stent

• US 5,500,013 A
• Filed: 01/13/1995
• Issued: 03/19/1996
• Est. Priority Date: 10/04/1991
• Status: Expired due to Term

• Current Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Wang, Lixiao, Buscemi, Paul J., Stejskal, Elizabeth A., Palme, Donald F. II
• Primary Examiner(s): Prebilic, Paul B.
• Application Number:
  US08/372,822
• Time in Patent Office: 431 Days
• Field of Search: 623/1, 623/11, 623/12, 606/151, 606/154, 606/192, 606/194, 606/153, 606/197, 606/199, 604/104
• US Class Current: 623/1.22
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2210/0023 operated at different temperatures whilst inside or touching the human body, heated or cooled by external energy source or cold supply
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2300/604 Biodegradation
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2300/622 Microcapsules
• CPC Class Codes: A61L 31/041 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/044 Collagen
• CPC Class Codes: A61L 31/047 Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: Y10S 623/901 Method of manufacturing prosthetic device

Abstract

A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.

Claims

1. A stent having a generally tubular main body formed from a helically coiled strip for insertion into a lumen of a vessel of a living being wherein the tubular main body comprises a substantially biodegradable matrix having voids within the matrix, and a biodegradable strengthening material in contact with the matrix to strengthen the matrix, the tubular main body being essentially saturated with drugs and further having an exterior surface for contacting the vessel when the main body is placed in a living being, a cambered interior surface for contacting a fluid passing through the lumen of the vessel, a leading end facing a direction of flow and a trailing end wherein the main body has substantially the same thickness at the leading end as at the trailing end.

2. The stent of claim 1 and further including a water soluble coating that overlays the interior surface.

3. The coiled strip of claim 1 and further including a meltable film coating that melts upon application of energy and that overlays the interior surface.

4. The stent of claim 1 wherein the biodegradable strengthening material is treated by an application of energy.

5. The stent of claim 4 wherein the energy causes an increase in temperature of the biodegradable strengthening material above a glass transition temperature of the biodegradable strengthening material.

6. The stent of claim 4 wherein the biodegradable strengthening material is treated by application of mechanical energy of a magnitude less than an elastic limit of the biodegradable strengthening material.

7. A stent having a generally tubular main body in the form of a coiled strip for insertion into a lumen of a vessel of a living being wherein the tubular main body comprises a substantially biodegradable matrix having voids within the matrix, and a biodegradable strengthening material in contact with the matrix to strengthen the matrix, the tubular main body being essentially saturated with drugs, and wherein the biodegradable strengthening material is treated by an application of energy, further including a plurality of microcapsules within the biodegradable strengthening material, the microcapsules containing a material inducing crosslinking of the biodegradable strengthening material wherein the application of energy causes a rupture of the microcapsules and a releasing of the material inducing crosslinking of the biodegradable strengthening material.

8. A stent having a generally tubular main body in the form of a coiled strip for insertion into a lumen of a vessel of a living being wherein the tubular main body comprises a substantially biodegradable matrix, and a biodegradable strengthening material in contact with the matrix to strengthen the matrix, and wherein the biodegradable strengthening material is treated by an application of energy, further including a plurality of microcapsules within the biodegradable strengthening material, the microcapsules containing a material inducing crosslinking of the biodegradable strengthening material wherein the application of energy causes a rupture of the microcapsules and a releasing of the material inducing crosslinking of the biodegradable strengthening material.