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Miniaturized planar columns in novel support media for liquid phase analysis

  • US 5,500,071 A
  • Filed: 10/19/1994
  • Issued: 03/19/1996
  • Est. Priority Date: 10/19/1994
  • Status: Expired due to Term
First Claim
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1. A method of forming a miniaturized column device comprising the steps of:

  • (a) providing a support body having first and second component halves, said support body halves having substantially planar interior surfaces;

    (b) forming a compartment in said support body by;

    (i) laser ablating a first microchannel in the interior surface of said first support body half;

    (ii) laser ablating a second microchannel in the interior surface of said second support body half, said second microchannel so arranged as to provide the mirror image of said first microchannel; and

    (iii) aligning said interior surfaces of said support body halves in facing abutment with each other whereby said microchannels define an elongate bore;

    (c) forming a plurality of ports in said support body, said ports enabling fluid communication between said compartment and associated external fluid containment means, wherein said step of forming said ports comprises laser ablating a plurality of apertures extending from at least one exterior surface of said support body and communicating with at least one microchannel, said apertures permitting the passage of fluid therethrough; and

    (d) forming detection means in said support body by laser ablating apertures through said first and second component halves, said apertures communicating with said compartment.

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