Process for the preparation of spherules of active principles and emulsions containing the spherules
First Claim
1. A process for preparing spherules of at least one active principle selected from alimentary principles and medicinal principles which comprises the steps of:
- (a) forming a primary oil-in-water emulsion comprising;
particles containing at least one of said active principles in oily form suspended in water, said water containing at least one protein;
(b) achieving controlled division of said primary oil-inwater emulsion by combining said primary oil-in-water emulsion with a water-immiscible solvent to create a second emulsion containing spherules of said primary oil-in-water emulsion;
(c) crosslinking said at least one protein contained in the epherules of said second emulsion by contacting said spherules with a crosslinking agent, wherein said crosslinking agent consists of glutaraldehyde; and
drying said spherules after said step (c) of crosslinking.
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Accused Products
Abstract
A process for the preparation of spherules and emulsions containing such spherules. A primary oil-in-water emulsion is formed containing particles comprising one or more active principles in oily form suspended in water, the water optionally containing at least one protein. Controlled division of the primary emulsion is achieved by combining the primary emulsion with a water-immiscible solvent to create a second emulsion containing spherules of the primary emulsion. Preferably, the particles of the primary emulsion have mean diameters of about 1 μm, and preferably, the spherules contained in the second emulsion have a diameter ranging from 100 μm to 500 μm. If protein is contained in the primary emulsion, the protein can be cross-linked. Further, the spherules can be separated from the water-immiscible solvent.
78 Citations
22 Claims
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1. A process for preparing spherules of at least one active principle selected from alimentary principles and medicinal principles which comprises the steps of:
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(a) forming a primary oil-in-water emulsion comprising; particles containing at least one of said active principles in oily form suspended in water, said water containing at least one protein; (b) achieving controlled division of said primary oil-inwater emulsion by combining said primary oil-in-water emulsion with a water-immiscible solvent to create a second emulsion containing spherules of said primary oil-in-water emulsion; (c) crosslinking said at least one protein contained in the epherules of said second emulsion by contacting said spherules with a crosslinking agent, wherein said crosslinking agent consists of glutaraldehyde; and drying said spherules after said step (c) of crosslinking. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification