Process and device for detection of obstructions in a perfusion line

• US 5,501,665 A
• Filed: 07/18/1994
• Issued: 03/26/1996
• Est. Priority Date: 09/30/1993
• Status: Expired due to Fees

• Current Assignee: Fresenius AG (Fresenius SE & Co. KGaA)
• Original Assignee: Becton, Dickinson & Co
• Inventors: Rebours, Pierre, Jhuboo, Abdel-Nasser
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Mendez, Manual
• Application Number:
  US08/276,300
• Time in Patent Office: 617 Days
• Field of Search: 604/30-34, 604/48, 604/49, 604/53, 604/65-67, 604/154, 604/250-256
• US Class Current: 604/65
• CPC Class Codes: A61M 5/16854 by monitoring line pressure

Abstract

A process for detecting obstructions in a perfusion line, wherein a programmable syringe pump uses a selected gradient constant and first and second pressure measurements from the perfusion line to determine whether an obstruction has occurred in the perfusion line.

Claims

1. Process for the detection of obstructions in a perfusion line, the process being characterized by the fact that it comprises the steps consisting of:

choosing a gradient constant;

measuring a first pressure in the perfusion line;

measuring a second pressure in the perfusion line after a time interval;

subtracting the first pressure from the second pressure to obtain a first pressure difference;

comparing the first pressure difference to the gradient constant; and

generating a signal if the first pressure difference exceeds or is equal to the gradient constant.

2. Process according to claim 1, characterized by the fact that it also comprises the steps consisting of:

measuring a second pressure in the diffusion line after a first time interval;

subtracting the first pressure from the second pressure to obtain a first pressure difference;

comparing the first pressure difference to the gradient constant;

measuring a third pressure after a second time interval;

subtracting the second pressure from the third pressure to obtain a second pressure difference;

comparing the second pressure difference to the gradient constant; and

generating a signal if the first pressure difference and the second pressure difference exceed the gradient constant.

3. Process according to claim 1, characterized by the fact that the gradient constant is a function of the flow rate.

4. Process according to claim 1, characterized by the fact that the gradient constant is directly proportional to the flow rate.

5. Process according to claim 2, characterized by the fact that the first and second time intervals are essentially equal.

6. Process according to claim 2, characterized by the fact that it comprises steps consisting of:

comparing the first pressure difference to the gradient constant;

comparing the second pressure difference to the gradient constant; and

generating the signal only if the first and second pressure differences both exceed the gradient constant.

7. Process according to claim 1, characterized by the fact that it also comprises a step with automatic modification of the time interval in inverse proportion to the fluid flow rate in the perfusion line.

8. Process according to claim 1, characterized by the fact that it also comprises a step with automatic adjustment of the time interval in response to a noise on the perfusion line.

9. Process according to claim 8, characterized by the fact that the time interval is automatically increased to reduce the influence of noise on the perfusion line.

10. Process according to claim 1, characterized by the fact that it also comprises a step with comparison of the first pressure difference to a constant and with adjustment of the first time interval if the first pressure difference exceeds the constant.

11. Process according to claim 10, characterized by the fact that the adjustment step comprises an increase in the first time interval.

12. Process according to claim 10, characterized by the fact that the constant is deduced from the gradient constant.

13. Process according to claim 10, characterized by the fact that the constant is the gradient constant multiplied by a scale change factor.

14. Process according to claim 13, characterized by the fact that the scale change factor is deduced empirically.

15. Process according to claim 1, characterized by the fact that it also comprises a step where the first pressure difference is compared to a constant and where the time interval is automatically adjusted if the first pressure difference is less than the constant.

16. Process according to claim 15, characterized by the fact that the adjustment step comprises a reduction of the time interval.

17. Process according to claim 1, characterized by the fact that it also comprises an optimization step for the first time interval.

18. Process according to claim 17, characterized by the fact that the optimization step uses a process by dichotomy.

19. Process according to claim 18, characterized by the fact that the optimization step comprises iteration steps to establish an initial time interval by comparing the first pressure difference to a constant.

20. Process according to claim 18, characterized by the fact that the optimization step comprises a time interval increase step if the absolute value of the first pressure difference exceeds a first constant and a time interval reduction step if the absolute value of the first pressure difference is less than a second constant.

21. Process according to claim 20, characterized by the fact that the time interval increase step comprises the doubling of the first time interval.

22. Process according to claim 20, characterized by the fact that the time interval reduction step comprises the step of dividing the first time interval by two.