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Dual analyte immunoassay for methamphetamine and amphetamine

  • US 5,501,987 A
  • Filed: 06/10/1994
  • Issued: 03/26/1996
  • Est. Priority Date: 06/16/1992
  • Status: Expired due to Term
First Claim
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1. In a dual analyte immunoassay for the detection of amphetamine and methamphetamine in a sample, wherein to the sample is added an antibody selective for amphetamine and an antibody selective for methamphetamine, and whereby the presence of amphetamine and/or methamphetamine is determined by measuring the amount of a labelled reagent which remains bound or unbound to such antibodies as a result of competitive displacement by an analyte which may be present in such sample, the improvement comprising utilizing as the labelled reagent an amphetamine of the formula:

  • ##STR3## wherein L is a detectable labelling moiety, A is a linkage group capable of physically or chemically binding to L, X is H2, O, S or NH, and n=1-6;

    the antibody selective for amphetamine is generated by an immunogen of the formula;

    ##STR4## and the antibody selective for methamphetamine is generated from an immunogen of the formula;

    ##STR5## where m and m'"'"' are ±

    1 or the same as n independently for the methamphetamine and amphetamine immunogens, and P is a poly (amino acid) having reactive amine groups.

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