System for pulse oximetry SPO.sub.2 determination

• US 5,503,148 A
• Filed: 11/01/1994
• Issued: 04/02/1996
• Est. Priority Date: 11/01/1994
• Status: Expired due to Term

• Current Assignee: Datex-Ohmeda Incorporated (GE Healthcare Technologies, Inc.)
• Original Assignee: Ohmeda, Inc. (Linde Plc)
• Inventors: Trumble, David W., Pologe, Jonas A.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US08/332,972
• Time in Patent Office: 518 Days
• Field of Search: 128/633, 128/664, 356/41
• US Class Current: 600/323
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips
• CPC Class Codes: A61B 5/6843 Monitoring or controlling sensor contact pressure
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: Y10S 128/925 Neural network

Abstract

The improved pulse oximeter preprocesses the sets of red and infrared signals received from the probe. The set of pairs of processed red and infrared data points are fitted to a linear equation to compute the slope of the best fit line through these data points and account for noise in both of these sets of data points. A measure of the linearity of the input data points, if less than a predetermined threshold, indicates that a distorted signal has been received from the probe. The computed slope of the best fit line is converted to a RRatio which is used in a empirical calibration formula to compute the average SpO₂ value.

Claims

1. Apparatus for measuring oxygen saturation of hemoglobin in arterial blood said apparatus connected to a probe which produces a series of sets of data values, each of said sets including first and second data values, each of said data values in a set being indicative of light absorption of arterial blood, said arterial blood having pulsatile and non-pulsatile components, each of said data values being measured at a respective one of two light wavelengths said apparatus comprising:

means for storing a plurality of said sets of data values received from said probe;

means for computing a ratio of a first effective optical extinction coefficient of said pulsatile component of said arterial blood at a first one of said two light wavelengths to a second effective optical extinction coefficient of said pulsatile component of said arterial blood at a second one of said two light wavelengths, said ratio of effective optical extinction coefficients being determined by two variable least squares processing n of said sets of data values, where n is a positive integer greater than 2, to compensate for noise in said sets of data values at both of said first and second wavelengths; and

means for determining said oxygen saturation of said hemoglobin using said ratio.

2. The apparatus of claim 1 further comprising:

means for calculating an error measure indicative of a reliability of said first and second stored data values, taken over m of said sets of data values, where m is a positive integer greater than 1.

3. The apparatus of claim 2 further comprising:

means for generating an error indication, indicative of the presence of data values of questionable validity in said stored first and second data values which are used to compute said ratio, when said error measure exceeds a predetermined boundary.

4. The apparatus of claim 1 wherein said computing means comprises:

means for filtering said n sets of said stored first and second data values;

means for processing said n sets of first and second filtered data values to compute terms proportional to said first effective optical extinction coefficient and proportional to said second effective optical extinction coefficient of said pulsatile component; and

means for determining said two variable least squares fit to obtain a best fit line though both of said processed first and second data values in said n sets to obtain a best fit to said processed values, accounting for presence of noise in both said first and second data values.

5. The apparatus of claim 4 wherein said calculating means comprises;

means for computing a linear correlation coefficient using said best fit line and said n sets of processed first and second data values to indicate a linearity of both said processed first end second data values in said n sets.

6. The apparatus of claim 5 further comprising:

means for generating an error indication, indicative of the presence of data values of questionable validity in at least one of said stored first and second data values which are used to compute said ratio, when said linear correlation coefficient is outside a predetermined boundary.

7. The apparatus of claim 4 wherein said computing means further comprises:

means for normalizing said n sets of processed first and second data values.

8. The apparatus of claim 4 wherein said determining means comprises:

means for computing a slope of said best line; and

means for determining oxygen saturation of said hemoglobin from said computed slope.

9. The apparatus of claim 1 further comprising:

means for filtering said sets of data values received from said probe to remove noise components therefrom.

10. A method for measuring oxygen saturation of hemoglobin in arterial blood from a series of sets of data values produced by a probe, each of said sets including first and second data values, each of said data values in a set being indicative of light absorption of arterial blood, said arterial blood having a pulsatile and non-pulsatile components at a respective one of two light wavelengths, comprising the steps of:

storing a plurality of said sets of data values received from said probe;

computing a ratio of first effective optical extinction coefficient of said pulsatile component of said arterial blood at a first one of said two light wavelength to second effective optical extinction coefficient of said pulsatile component of said arterial blood at a second one of said two light wavelengths said ratio of effective optical extinction coefficients being determined by two variable least squares processing n of said sets of data values, where n is a positive integer greater than 2, to compensate for noise in said sets of data values at both of said first and second wavelengths; and

determining oxygen saturation of said hemoglobin using said ratio.

11. The method of claim 10 further comprising the step of:

calculating an error measure indicative of a reliability in said first and second stored data values, taken over m of said sets of data values, where m is a positive integer greater than 1.

12. The method of claim 11 further comprising the step of:

generating an error indication, indicative of the presence of data values of questionable validity in said stored first and second data values which are used to compute said ratio, when said error measure exceeds a predetermined boundary.

13. The method of claim 10 wherein said step of computing comprises:

filtering said n sets of stored first and second data values;

processing said n sets of first and second filtered data values to compute terms proportional to said first effective optical extinction coefficient and proportional to said second effective optical extinction coefficient of said pulsatile component; and

determining said two variable least squares fit to obtain a best fit line though both of said processed first and second data values in said n sets to obtain a best fit to said processed values, accounting for presence of noise in both said first and second data values.

14. The method of claim 13 wherein said step of calculating further comprises:

computing a linear correlation coefficient using said best fit line and said n sets of processed first and second data values to indicate a linearity of both of said processed first and second data values in said n sets.

15. The method of claim 14 further comprising the step of:

generating an error indication, indicative of the presence of data values of questionable validity in at least one of said stored first and second data values which are used to compute said ratio, when said linear correlation coefficient is outside a predetermined boundary.

16. The method of claim 13 wherein said step of computing further comprises:

normalizing said n sets of processed first and second data values.

17. The method of claim 13 wherein said step of determining comprises:

computing a slope of said best fit line; and

determining said oxygen saturation of said hemoglobin from said computed slope.

18. The method of claim 10 further comprising the steps of:

filtering said sets of data values received from said probe to remove noise components therefrom.