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Osseointegration promoting implant composition, implant assembly and method therefor

  • US 5,503,558 A
  • Filed: 11/12/1993
  • Issued: 04/02/1996
  • Est. Priority Date: 11/12/1993
  • Status: Expired due to Term
First Claim
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1. In a method of placing an implant in bone, in which a bore is formed in the bone and the implant is inserted into the bone, the improvement in which a liquid composition comprising a transforming growth factor β

  • (TGF-β

    ) in a liquid carrier is injected into said bore prior to insertion of the implant in the bore, said liquid carrier being gelable at about 37°

    C., and said TGF-β

    being present in said liquid composition in a concentration effective in an interspace between an inner surface of said bore and an outer surface of said implant, to promote osseointegration at the interface between said inner surface and said outer surface.

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