Patient-fillable hypodermic jet injector

• US 5,503,628 A
• Filed: 03/15/1995
• Issued: 04/02/1996
• Est. Priority Date: 03/15/1995
• Status: Expired due to Fees

• Current Assignee: Jettek Incorporated
• Original Assignee: Jettek Incorporated
• Inventors: Schwebel, Paul R. M., Fetters, G. David
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): VANOVER, PERRY
• Application Number:
  US08/404,581
• Time in Patent Office: 384 Days
• Field of Search: 604/68, 604/72, 604/69, 604/232, 604/134-137, 604/186-187, 604/151-157, 604/207-211, 604/218, 604/228, 604/181, 222/325-326
• US Class Current: 604/72
• CPC Class Codes: A61M 2005/3117 Means preventing contamination of the medicament compartment of a syringe
• CPC Class Codes: A61M 2005/3128 Incorporating one-way valves, e.g. pressure-relief or non-return valves
• CPC Class Codes: A61M 5/1782 Devices aiding filling of syringes in situ combination of a vial and a syringe for transferring or mixing their contents A61J1/2096, filling of medical containers in general B65B3/003
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/2046 Media being expelled from injector by gas generation, e.g. explosive charge
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/31525 Dosing burettes, pipettes B01L3/02
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member

Abstract

A hypodermic jet injector employing self-contained, patient fillable, thin-walled disposable ampules. Each ampule includes an elongate plastic body with an injection orifice at a first end, an internal propellant at a closed second end, and a double piston slidably and sealingly mounted within the body entirely between the orifice and the internal propellant, and also includes an auxiliary access opening in the ampule side wall. An ampule chamber with a corresponding access opening in its side wall is provided to receive and support the thin-walled ampule. The main body of the ampule is molded with draft angles, and the double piston construction includes a soft rubber plunger and a relatively hard plunger to the front and rear, respectively, of the auxiliary access opening in the ampule, with the two plungers interconnected by a connecting rod spanning the central section of the ampule. The ampule chamber is provided with a draft angle in the front section of its bore adjacent to the soft plunger in the ampule, and a straight bore in the rear section adjacent to the hard plunger in the ampule. The injector includes a high-resolution metered filling device located parallel to the ampule chamber and including a piston engagement member which is laterally movable into contact with the connecting rod, which consequently moves under control of the filling device. The metered filling device includes a digital dosage display including a drum bearing a plurality of dosage values in integer form arranged in a spiral pattern on its surface, and a dosage selection window positioned so as to expose a single dosage value at a time.

Claims

1. A self-contained, patient-fillable ampule for a jet injector, comprising:

an elongate ampule body having an injection orifice at a first end, a propellant at a second end, and a hollow portion therebetween;

a piston slidably and sealingly mounted in said hollow portion of said ampule body; and

an auxiliary access opening in said ampule body in proximity to said piston.

2. The ampule of claim 1, wherein said auxiliary access opening is elongated and extends into said hollow portion of said ampule body.

3. The ampule of claim 2, wherein said piston includes front and rear seals and a connecting rod therebetween, said connecting rod having at least one transverse cross-sectional dimension less than that of said front and rear seals, and wherein said auxiliary access opening is adjacent to said connecting rod.

4. The ampule of claim 3, wherein said front seal is softer than said rear seal.

5. The ampule of claim 4, wherein said propellant is an explosive charge.

6. A self-contained, disposable ampule for a jet injector, comprising:

an elongate ampule body having an injection orifice at a first end, a propellant at a second end, and a hollow portion therebetween which is internally tapered along its longitudinal axis, said hollow portion having an expandable wall structure; and

a first plunger slidably and sealingly mounted in said hollow portion of said ampule body.

7. The ampule of claim 6, wherein said expandable wall structure of said hollow portion of said ampule body is plastic with a wall thickness of approximately 0.030".

8. The ampule of claim 7, further comprising a compressible plunger slidably and sealingly mounted in said hollow portion of said ampule body between said first end and said first plunger, and a connecting rod connected between said compressible plunger and said first plunger, wherein said first plunger is relatively non-compressible.

9. The ampule of claim 8, further comprising an auxiliary access opening into said hollow portion adjacent to said connecting rod.

10. A self-contained disposable ampule, comprising:

an elongate plastic body with an injection orifice at its first end and an internal propellant at a closed second end; and

a piston slidably and sealingly mounted within said body entirely between said orifice and said internal propellant, said piston and said body together defining a medicine chamber and a combustion chamber within said ampule, said medicine chamber and combustion chamber having expandable sidewalls of insufficient strength to independently withstand normal peak operating pressures developed during an injection.

11. A hypodermic jet injector, comprising:

a self-contained disposable ampule, said ampule having an elongate plastic body with an injection orifice at its first end and an internal propellant at a closed second end, and a piston slidably and sealingly mounted within said body entirely between said orifice and said internal propellant, said piston and said body together defining a medicine chamber and a combustion chamber within said ampule, said medicine chamber and combustion chamber having expandable sidewalls of insufficient strength to independently withstand normal peak operating pressures developed during an injection; and

an ampule chamber having rigid body means for receiving said self-contained ampule and supporting said expandable sidewalls.

12. A patient-fillable hypodermic jet injector, comprising:

an ampule chamber, said ampule chamber having a rigid body defining an elongate bore with forward, central and rear sections, a front opening smaller in cross-section than the central section of said bore, and an auxiliary access opening into said bore; and

an ampule piston engagement member movably mounted with respect to said auxiliary access opening, said ampule piston engagement member having a portion movable through said auxiliary access opening into said bore and into operative engagement with a piston in an ampule loaded in said ampule chamber.

13. The hypodermic jet injector of claim 12, wherein said auxiliary access opening is located in said central section and wherein said ampule chamber further includes a rear opening.

14. The hypodermic jet injector of claim 13, wherein said forward bore section includes a relatively long main portion with a minor taper and a relatively short front portion with a major taper in communication with said front opening, and wherein said rear bore section is a straight bore.

15. The hypodermic jet injector of claim 14, wherein said central bore section also has a straight bore, wherein the diameter of said central bore section is less than that of said rear bore section, and wherein the maximum diameter of said tapered bore section is less than the diameter of said central bore section.

16. The hypodermic jet injector of claim 15, wherein said elongate bore is circular in cross-section throughout its length.

17. The hypodermic jet injector of claim 16, wherein said rigid body is integrally formed.

18. A high-resolution metered filling device for a hypodermic jet injector, comprising:

a rotary-to-linear filling actuator including a linear drive member threaded to a rotary drive member;

a digital dosage display connected to said actuator and synchronously responsive to said rotary drive member, said display including a drum bearing a plurality of dosage values in integer form arranged in a spiral pattern on its surface, and a drum cover threadedly connected to said drum with a thread pitch matching the pitch of said spiral pattern, said drum cover extending over said drum and having a dosage selection window therein slightly greater in size than one of said integer values and in registry with said spiral pattern, whereby a single dosage value is visible at a time through said window during rotation of said drum relative to said window.

19. The high-resolution metered filling device of claim 18, wherein said rotary drive member and said drum are mounted on a common shaft.

20. The high-resolution metered filling device of claim 19, wherein said rotary drive member has a thread pitch less than the pitch of said spiral pattern.

21. The high-resolution metered filling device of claim 20, wherein said dosage values include a nonlinear series of numbers equally spaced along the spiral path.

22. The high-resolution metered filling device of claim 21, further comprising a piston engagement member slidably connected to said linear drive member and movable with respect thereto along an axis perpendicular to the axis of said common shaft, said piston engagement member adapted for engagement with a piston in an ampule through a sidewall of the ampule.

23. The high-resolution metered filling device of claim 22, further comprising a housing having an upper surface over a portion of said drum cover provided with means for simulating the appearance of medicine filling the injector.