Antimicrobial compositions, process for preparing the same and use

• US 5,503,840 A
• Filed: 10/20/1993
• Issued: 04/02/1996
• Est. Priority Date: 08/09/1991
• Status: Expired due to Term

• Current Assignee: E. I. du Pont de Nemours and Company (Corteva, Inc.)
• Original Assignee: E. I. du Pont de Nemours and Company (Corteva, Inc.)
• Inventors: Jacobson, Howard W., Wigfall, Annie W., Scholla, Michael H.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): LEVY, NEIL S
• Application Number:
  US08/139,962
• Time in Patent Office: 895 Days
• Field of Search: 424/405, 424/404, 424/421, 424/490, 424/619, 424/635, 424/724
• US Class Current: 424/421
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/26 in coated particulate form
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A01N 59/20 Copper
• CPC Class Codes: A46D 1/00 Bristles; Selection of materials for bristles making artificial bristles D01D, D01F
• CPC Class Codes: A46D 1/006 Antimicrobial, disinfectant bristles, handle, bristle-carrier or packaging
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C01P 2004/10 extending in one dimension, e.g. needle-like
• CPC Class Codes: C01P 2004/20 extending in two dimensions, e.g. plate-like
• CPC Class Codes: C01P 2004/61 Micrometer sized, i.e. from 1-100 micrometer
• CPC Class Codes: C01P 2004/62 Submicrometer sized, i.e. from 0.1-1 micrometer
• CPC Class Codes: C01P 2004/64 Nanometer sized, i.e. from 1-100 nanometer
• CPC Class Codes: C01P 2004/80 Particles consisting of a mixture of two or more inorganic phases
• CPC Class Codes: C01P 2004/82 two phases having the same anion, e.g. both oxidic phases
• CPC Class Codes: C01P 2006/12 Surface area
• CPC Class Codes: C01P 2006/20 Powder free flowing behaviour
• CPC Class Codes: C01P 2006/60 Optical properties, e.g. expressed in CIELAB-values
• CPC Class Codes: C01P 2006/80 Compositional purity
• CPC Class Codes: C01P 2006/90 Other properties not specified above
• CPC Class Codes: C08K 9/02 : Ingredients treated with inorganic substances
• CPC Class Codes: C08K 9/04 : Ingredients treated with organic substances treated with macromolecular compounds C08K9/08
• CPC Class Codes: C09C 1/3661 : Coating
• CPC Class Codes: C09C 1/3669 : Treatment with low-molecular organic compounds
• CPC Class Codes: C09C 3/08 : Treatment with low-molecular-weight non-polymer organic compounds C09C3/006, C09C3/048 take precedence
• CPC Class Codes: D01F 1/103 : Agents inhibiting growth of microorganisms
• CPC Class Codes: D01F 6/60 : from polyamides from polyamino acids or polypeptides D01F6/68
• CPC Class Codes: D01F 6/62 : from polyesters
• CPC Class Codes: D01F 6/70 : from polyurethanes

Abstract

An antimicrobial composition of titanium dioxide, barium sulfate, zinc oxide particles, and mixtures thereof having successive coatings of silver, in some cases a coating of zinc and/or copper compounds such as zinc oxide, copper (II) oxide and zinc silicate; silicon dioxide; alumina; and a dispersion aid such as dioctyl azelate.

Claims

1. An antimicrobial composition consisting essentially of coated core particles wherein the core particles consist essentially of a mixture of at least two members selected from the group consisting of titania, barium sulfate and zinc oxide that have an average diameter between about 0.005 to about 3.0 microns, wherein said core particles are coated successively based upon said particles, with (a) about 0.2 to at least about 1 weight % silver, (b) about 0.2 to at least about 0.8 weight % of at least one member from the group of zinc, zinc oxide, zinc silicate, copper, and copper (II) oxide, (c) about 0.2 to 5 weight % of a protective coating;

(d) about 1 to at least about 3 weight % of a dispersion coating; and

Led about 0.2 to 3 weight % of a dispersion aid.

3. The composition of claim 1 wherein the protective coating is silica.

4. The composition of claim 1 wherein the dispersion coating is alumina.

5. The composition of claim 1 wherein the dispersion aid is at least one member from the group of dioctyl azelate and trimethylolpropane.

6. The composition of claim 1 wherein one of the core particles is zinc oxide that is coated successively with silver, silica, alumina and dioctyl azelate.

7. The composition of claim 1 wherein the mixture of inorganic particles is titania and barium sulfate that are coated successively with silver;

at least one member selected from the group consisting of copper oxide, zinc silicate and zinc oxide;

silica;

alumina; and

dioctyl azelate.

8. In an antimicrobial, shaped polymer article, a polymeric carrier matrix comprising at least one polymer and about 0.1% to at least about 5% by weight, based on the total weight of the shaped polymer article, of the antimicrobial composition of claims 1, 6, 7 or 2.

9. The antimicrobial, shaped polymer article of claim 8 wherein the polymeric carrier matrix is a fiber.

10. The antimicrobial, shaped polymer article of claim 8 wherein the polymer is at least one polymer selected from the group consisting of nylon 6,6, nylon 6,12 and spandex.

11. The antimicrobial, shaped polymer article of claim 8 wherein the whiteness of the article is defined as having a Delta E of less than about 15.

12. A compounded master batch for use in making a fiber comprising (a) nylon 66/6-10/6 resin, (b) nylon 6,6, and (c) an effective amount of the antimicrobial powder of claims 1, 6, 7 or 2.

13. The antimicrobial, shaped polymer article of claim 8 or 11 wherein the antimicrobial activity of the article is defined by a 24 Hour Kt of at least about 1.0.

2. An antimicrobial composition consisting essentially of about 40 to 60% titania particles and about 40 to 60% barium sulphate particles wherein both of said particles are successively coated based upon said particles, with about 0.2 to 1% wt. Ag, about 0.2 to about 0.8% CuO, about 0.2 to about 5% SiO₂, about 1 to about 3% Al₂ O₃ ;

and about 0.2 to 3% dioctyl azelate.