Microencapsulation of water-soluble medicaments
First Claim
1. A process for the microencapsulation of water-soluble active ingredients according to the principle of phase separation which comprises the steps of:
- a) preparing a solution of a biocompatible polymer in an organic solvent;
b) adding an aqueous solution of one or more active ingredients to or dispersing one or more solid active ingredients in the solution from stage (a);
c) adding a coacervation agent to the emulsion or the dispersion from stage (b) forming microcapsules in the solution;
d) introducing the mixture from stage (c) into an excess of a liquid, non-hydrogenated hardening agent; and
e) separating the microcapsules from the hardening agent, collecting and washing the microcapsules to remove substantially all of the hardening agent,wherein liquid, non-hydrogenated natural or synthetic esters of saturated C4 to C18 carboxylic acids and polyhydric alcohols are used as hardening agent in an excess amount of up to 30 times the total volume of polymer solvent and coacervation agent.
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Abstract
In a process for the microencapsulation of water-soluble active ingredients according to the principle of phase separation, which comprises the steps
(a) Preparation of a solution of a biocompatible polymer in an organic solvent;
(b) Addition of an aqueous solution of one or more active ingredients or dispersion of one or more solid active ingredients in the solution from stage (a);
(c) Addition of a coacervation agent to the emulsion or dispersion from stage (b);
(d) Introduction of the mixture from stage (c) into an excess of a hardening agent;
(e) Collection and washing of the microcapsules,
natural or synthetic esters of saturated C4 to C18 carboxylic acids and polyhydric alcohols are used as hardening agents.
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Citations
20 Claims
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1. A process for the microencapsulation of water-soluble active ingredients according to the principle of phase separation which comprises the steps of:
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a) preparing a solution of a biocompatible polymer in an organic solvent; b) adding an aqueous solution of one or more active ingredients to or dispersing one or more solid active ingredients in the solution from stage (a); c) adding a coacervation agent to the emulsion or the dispersion from stage (b) forming microcapsules in the solution; d) introducing the mixture from stage (c) into an excess of a liquid, non-hydrogenated hardening agent; and e) separating the microcapsules from the hardening agent, collecting and washing the microcapsules to remove substantially all of the hardening agent, wherein liquid, non-hydrogenated natural or synthetic esters of saturated C4 to C18 carboxylic acids and polyhydric alcohols are used as hardening agent in an excess amount of up to 30 times the total volume of polymer solvent and coacervation agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification
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- Resources
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Current AssigneeFerring GmbH
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Original AssigneeFerring Arzneimittel GmbH
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InventorsGustafsson, Jan, Kochling, Wolfgang, Nerlich, Birgit, Mank, Reinhard, Horig, Joachim
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Primary Examiner(s)Seidleck, James J.
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Assistant Examiner(s)COONEY, JOHN M
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Application NumberUS08/084,592Time in Patent Office1,006 DaysField of Search424/489, 424/501, 424/502US Class Current424/489CPC Class CodesA61K 9/1647 Polyesters, e.g. poly(lacti...A61K 9/1694 resulting in granules or mi...
