Human cancer inhibitory pentapeptide methyl esters
First Claim
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1. A composition of matter having the general structure shown below wherein:
- ##STR4## R is selected from the group consisting of the substituents shown above, R1 is selected from the group consisting of the substituents shown above, and R.sub. 2 is selected from the group consisting of the substituents shown above.
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Abstract
Herein disclosed are several pentapeptide methyl ester derivatives of dolatin 10, using both naturally occurring and modified amino acids. The selected modified amino acids are constituents of dolastatin 10 which is a structurally distinct peptide with excellent in vitro and in vivo antineoplastic activity. The structures of these compounds are as shown below: ##STR1##
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6 Claims
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1. A composition of matter having the general structure shown below wherein:
- ##STR4## R is selected from the group consisting of the substituents shown above, R1 is selected from the group consisting of the substituents shown above, and R.sub. 2 is selected from the group consisting of the substituents shown above.
- View Dependent Claims (2, 3, 4, 5, 6)
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