Heat-activated drug delivery system and thermal actuators therefor

• US 5,505,706 A
• Filed: 08/24/1993
• Issued: 04/09/1996
• Est. Priority Date: 01/10/1989
• Status: Expired due to Term

• Current Assignee: Daryl D. Maus, Scott F. Tibbitts
• Original Assignee: Daryl D. Maus, Scott F. Tibbitts
• Inventors: Tibbitts, Scott F., Maus, Daryl D.
• Primary Examiner(s): WEISS, JOHN
• Application Number:
  US08/110,876
• Time in Patent Office: 959 Days
• Field of Search: 60/528, 60/527, 604/150, 604/896.1, 604/891.2, 604/131, 604/141, 604/143, 604/145, 604/151, 212/386, 212/327, 212/54
• US Class Current: 604/131
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/3613 by body heat
• CPC Class Codes: A61M 2205/3653 by Joule effect, i.e. electric resistance
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure
• CPC Class Codes: A61M 5/16831 Monitoring, detecting, signalling or eliminating infusion flow anomalies low-level float-valves causing cut-off A61M5/40; indicating or recording presence, absence or direction of flow in general G01P13/0066
• CPC Class Codes: F03G 7/06 using expansion or contraction of bodies due to heating, cooling, moistening, drying or the like using thermal expansion of non-vaporising liquids F01K

Abstract

A thermal actuator, also known as a heat capacitance motor, derives its energy from the physical expansion of paraffin wax as it changes from solid to liquid when heated within an enclosure such as a cylinder. This energy is converted into mechanical force which causes translation of a piston slidably mounted within the cylinder, thus creating hydrostatic pressure which is converted to work. The thermal actuator may be utilized in various drug delivery systems in which the hydrostatic pressure created by the actuator is used expel the contents of a syringe.

Claims

1. A portable drug delivery system to be worn on the body of a patient, said system comprising:

a) a syringe having an outlet formed at one end;

b) a discharge assistant mounted for movement within said syringe, a portion of said syringe between said discharge assistant and said outlet defining a variable volume compartment for containing a drug; and

c) motive means mounted within said syringe, said motive means including a thermally responsive expansion material for creating hydraulic pressure in response to a temperature increase, actuator means for converting said hydraulic pressure to linear motion and an output shaft engaging said discharge assistant to cause said discharge assistant to move toward said outlet, expelling said drug from said variable volume compartment at a controlled rate.

2. The drug delivery system of claim 1, wherein said motive means is mounted for movement with said syringe.

3. The drug delivery system according to claim 1, wherein said thermally responsive expansion material comprises paraffin.

4. The drug delivery system according to claim 1, wherein said thermally responsive material comprises a material which undergoes a solid-liquid phase change at a temperature greater than ambient temperature.

5. The drug delivery system of claim 1, further comprising an occlusion safety device for preventing excessive pressure build-up in said system, said safety device comprising:

a) shaft means coupled to said motive means and extending away from said outlet of said syringe;

b) means for frictionally capturing said shaft means to prevent rearward movement thereof in response to blockage in the system and for releasing said shaft when pressure in said system exceeds a predetermined maximum.

6. An infusion system according to claim 1, further comprising electric heating means surrounding said expansion material for causing said expansion material to expand.

7. The drug delivery system according to claim 1, wherein said motive means comprises:

a) a linear stepping motor; and

b) a crawler unit for allowing said motor to move incrementally down said syringe, said crawler unit including

i) a cradle portion for carrying said motor,

ii) a forward gripping unit configured to grip the inner surface of said syringe when the output shaft of said motor is retracted and to release the inner surface of said syringe when the output shaft is extended,

iii) expandable and contractible biasing means for coupling said forward gripping unit to the front of said cradle and urging said cradle toward said forward gripping unit, and

iv) a rear gripping unit secured to the rear of said motor and configured to grip the inner surface of said syringe when the output shaft of said motor is extended and to release the inner surface of said syringe when the output shaft is retracted.

8. The drug delivery system according to claim 7, wherein said thermally responsive material comprises a material which undergoes a solid-liquid phase change at a temperature greater than ambient temperature.

9. A fluid dispensing system comprising:

a) an enclosure defining an interior chamber and

having an outlet formed at one end;

b) a discharge assistant mounted for movement within said chamber, a portion of said interior chamber between said discharge assistant and said outlet defining a variable volume compartment for containing a fluid; and

c) motive means mounted for movement within said enclosure, said motive means including an output shaft engaging said discharge assistant to cause said discharge assistant to move toward said outlet, expelling said fluid from said variable volume compartment, said motive means further including;

a linear stepping motor, and

a crawler unit for allowing said motor to move incrementally down said interior chamber, said crawler unit including;

i) a cradle portion for carrying said motor,

ii) a forward gripping unit configured to grip the inner surface of said enclosure when the output shaft is extended,

iii) expandable and contractible biasing means for coupling said forward gripping unit to the front of said cradle and urging said cradle toward said forward gripping unit, and

iv) a rear gripping unit secured to the rear of said motor and configured to grip the inner surface of said enclosure when the output shaft of said motor is extended and to release the inner surface of said enclosure when the output shaft is retracted.

10. The fluid dispensing system of claim 9, wherein said motive means comprises:

a) a thermally responsive expansion material for creating hydraulic pressure in response to a temperature increase; and

b) actuator means for converting said hydraulic pressure to linear motion.

11. The fluid dispensing system according to claim 10, further comprising electric heating means surrounding said expansion material for causing said expansion material to expand.

12. The fluid system according to claim 10, wherein said thermally responsive expansion material is paraffin.

13. The fluid system according to claim 10, wherein said thermally responsive expansion material comprises a material which undergoes a solid liquid phase change at a temperature greater than ambient temperature.