Indwelling catheter with stable enzyme coating
First Claim
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1. A catheter, comprising:
- an elongated tubular element formed from a polymeric material and adapted for patient placement, said tubular element defining a catheter lumen; and
a surface coating applied to said tubular element on at least a portion of the surface thereof, said surface coating including at least one enzyme effective to dissolve occlusions along said catheter lumen, said at least one enzyme comprising a lipolytic enzyme, and means for protecting said enzyme against short-term degradation upon contact with patient body fluids;
said surface coating comprising a membrane having the enzyme cross linked with a serum protein which includes albumin and bonded to said tubular element, and wherein said at least one enzyme comprises phospholipase.
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Accused Products
Abstract
An improved indwelling catheter adapted for long-term usage includes a stable enzyme coating to prevent occlusion of the catheter lumen. The enzyme coating includes a fibrinolytic and/or lipolytic enzyme incorporated in a catheter coating to resist or control proteolytic degradation, thereby maintaining the enzyme in an active state for dissolving clots and occlusions within the catheter lumen over an extended period of time.
241 Citations
10 Claims
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1. A catheter, comprising:
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an elongated tubular element formed from a polymeric material and adapted for patient placement, said tubular element defining a catheter lumen; and a surface coating applied to said tubular element on at least a portion of the surface thereof, said surface coating including at least one enzyme effective to dissolve occlusions along said catheter lumen, said at least one enzyme comprising a lipolytic enzyme, and means for protecting said enzyme against short-term degradation upon contact with patient body fluids; said surface coating comprising a membrane having the enzyme cross linked with a serum protein which includes albumin and bonded to said tubular element, and wherein said at least one enzyme comprises phospholipase. - View Dependent Claims (2, 3)
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4. A catheter, comprising:
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an elongated tubular element formed from a polymeric material and adapted for patient placement, said tubular element defining a catheter lumen; and at least one enzyme on at least a portion of the surface of said tubular element, said enzyme being effective in the presence of patient body fluids to dissolve lipid-based occlusions along said catheter lumen. - View Dependent Claims (5, 6)
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7. A method of applying an enzyme coating to a polymeric catheter, said method comprising the steps of:
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cross link bonding at least one lipolytic enzyme which includes phospholipase with a serum protein which includes albumin by means of a cross link agent; and bonding the cross link agent to at least a portion of the surface of the catheter. - View Dependent Claims (8, 9, 10)
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Specification