Multiple tube perfusion sampler

• US 5,505,721 A
• Filed: 09/16/1993
• Issued: 04/09/1996
• Est. Priority Date: 09/16/1993
• Status: Expired due to Fees

• Current Assignee: Albert C. Phelps, Gregory L. Leach, Mark L. Krebs
• Original Assignee: Albert C. Phelps, Gregory L. Leach, Mark L. Krebs
• Inventors: Krebs, Mark L., Phelps, Albert C., Leach, Gregory L.
• Primary Examiner(s): Green, Randall L.
• Assistant Examiner(s): ZUTTARELLI, ANTHONY
• Application Number:
  US08/122,930
• Time in Patent Office: 936 Days
• Field of Search: 128/760, 128/762, 128/763, 128/764, 128/766, 604/257-258, 604/272-273, 604/317, 604/403, 604/407, 604/411-415, 604/191, 604/82
• US Class Current: 604/403
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150251 Collection chamber divided into at least two compartments, e.g. for division of samples injection syringes having more than one chamber A61M5/19; syringes for injection of two or more media A61M5/2448, A61M5/284; sample preparation for further analysis A61B5/150755
• CPC Class Codes: A61B 5/150351 Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel caps for bottles or containers in general B65D41/00
• CPC Class Codes: A61B 5/150389 Hollow piercing elements, e.g. canulas, needles, for piercing the skin
• CPC Class Codes: A61B 5/150488 Details of construction of shaft
• CPC Class Codes: A61B 5/150496 Details of construction of hub, i.e. element used to attach the double-ended needle to a piercing device or sampling device
• CPC Class Codes: A61B 5/150519 Details of construction of hub, i.e. element used to attach the single-ended needle to a piercing device or sampling device
• CPC Class Codes: A61B 5/150656 semi-automatically triggered, i.e. in which the triggering of the protective sleeve requires a deliberate action by the user, e.g. manual release of spring-biased extension means
• CPC Class Codes: A61B 5/150732 Needle holders, for instance for holding the needle by the hub, used for example with double-ended needle and pre-evacuated tube,
• CPC Class Codes: A61B 5/154 Devices using pre-evacuated means
• CPC Class Codes: A61B 5/155 Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146

Abstract

An apparatus for withdrawing blood from a vein and simultaneously filling multiple collection tubes. The apparatus includes a movable sheath which protects the technician from inadvertently contacting the withdrawn needle after use and a laminar flow transition chamber between the blood withdrawal needle and the multiple collection tubes.

Claims

1. A multiple sample blood collection device comprising;

a. an elongated, generally cylindrical, blood sample tube holder having first and second ends, said first end including a plurality of apertures symmetrically disposed about the central axis of said tube holder and adapted to receive individual evacuated blood sample tubes;

b. a venipuncture needle positioned in said second end coaxially positioned on said central axis of said holder, said venipuncture needle having a first end for insertion into the body from which blood is to be drawn and a second end positioned within said tube holder;

c. a sample tube filling needle positioned within each of said apertures in said tube holder and having a first end for insertion into an evacuated sample tube and a second end for receiving blood from said venipuncture needle;

d. an elastomeric nipple affixed to said sample tube holder and positioned over said first end of said sample tube filling needle to prevent flow of blood unless punctured by said first end of said sample tube filling needle when said first end is inserted into an evacuated sample tube;

e. a manifold chamber connecting said second end of said venipuncture needle and said second ends of each of said sample tube filling needles;

f. said manifold chamber comprising a central chamber portion symmetrically arranged with respect to said second end of said venipuncture needle and a plurality of sample tube filling passages branching therefrom in symmetrical relationship whereby laminar flow of blood is maintained during transfer of blood from second end of said venipuncture needle to said second end of said sample tube filling needle to minimize the damage to red blood cells during blood sample collection;

g. a loader for multiple sample tubes, and a first end of said loader having a plurality of sample tube cavities therein, each said sample tube cavity being arranged for alignment with a corresponding one of said plurality of apertures in said blood sample tube holder;

h. wherein said sample tube loader includes a second end, opposite said first end, for the application of force to move sample tubes held therein into said plurality of apertures and cause said first ends of said sample tube filling needles to puncture said elastomeric nipples and plugs in the open ends of sample tubes; and

,

i. wherein said sample tube loader has a centrally positioned stop portion on said first end adapted to engage said sample tube holder and limit the distance to which said sample tubes may be inserted into said holder.

2. A multiple sample tube blood collection device according to claim 1 wherein said sample tube cavities in said sample tube loader have an inner dimension slightly less than the outer dimension of said sample tubes whereby said sample tubes are held with said loader by frictional force.

3. A multiple sample blood collection device according to claim 1 wherein said manifold includes a blood flow divider opposite said second end of said venipuncture needle and centrally positioned within the stream of blood emerging from said venipuncture needle at a distance approximately ten times the internal diameter of said venipuncture needle.

4. A multiple sample blood collection device according to claim 3 wherein said blood flow divider is of generally conical shape.

5. A multiple sample blood flow collection device according to claim 4 wherein said conical blood flow divider terminates in a spherical shape having a diameter between 0.5 mm and 1.0 mm.

6. A multiple blood sample blood collection device according to claim 1 wherein each of said manifold sample tube filling passages have a curved diverging portion extending from said blood flow divider and a curved axial alignment portion extending to said second end of said sample tube filling needle whereby laminar flow of blood is maintained throughout said manifold.

7. A multiple blood sample blood collection device according to claim 1 adapted for use with sample tubes having a nominal diameter less than 13 mm and a nominal length of less than 75 mm.

8. A multiple sample blood collection device comprising:

a. an elongated, substantially cylindrical, blood sample tube holder having first and second ends, said first end including a plurality of apertures symmetrically disposed about the central axis of said tube holder and adapted to receive individual evacuated blood sample tubes having an external diameter of less than 8 mm;

b. a venipuncture needle positioned in said second end coaxially positioned on said central axis of said holder, said venipuncture needle having a first end for insertion into the body from which blood is to be drawn and a second end positioned within said tube holder;

c. a sample tube filling needle positioned within each of said apertures in said tube holder and having a first end for insertion into an evacuated sample tube and a second end for receiving blood from said venipuncture needle;

d. an elastomeric nipple affixed to said sample tube holder and positioned over said first end of said sample tube filling needle to prevent flow of blood unless punctured by said first end of said sample tube filling needle when said first end is inserted into an evacuated sample tube;

e. a manifold chamber connecting said second end of said venipuncture needle and said second ends of each of said sample tube filling needles;

f. said manifold chamber comprising a central chamber portion symmetrically arranged with respect to said second end of said venipuncture needle and a plurality of sample tube filling passages branching therefrom in a symmetrical relationship whereby laminar flow of blood is maintained during the passage of blood from second end of said venipuncture needle to said second end of said sample tube filling needle to minimize the damage to blood cells during the blood sample collection procedure;

g. a loader for simultaneously inserting multiple sample tubes into said holder;

h. a first end of said loader having a plurality of sample tube cavities therein, each said sample tube cavity having an internal diameter less than 8 mm and arranged for alignment with a corresponding one of said plurality of apertures in said blood sample tube holder;

i. a loader for multiple sample tubes, and a first end of said loader having a plurality of sample tube cavities therein, each said sample tube cavity being arranged for alignment with a corresponding one of said plurality of apertures in said blood sample tube holder; and

,

j. wherein said sample tube loader has a centrally positioned stop portion on said first end adapted to engage said sample tube holder and limit the distance to which said sample tubes may be inserted into said holder.

9. A multiple sample blood collection device according to claim 8 wherein said sample tube loader includes a second end, opposite said first end, for the application of force to move sample tubes held therein into said plurality of apertures and cause said first end of said sample tube filling needles to puncture plugs in the open ends of said sample tubes.

10. A multiple sample tube blood collection device according to claim 8 wherein said sample tube cavities in said sample tube loader have an inner dimension slightly less than the outer dimension of said sample tubes whereby said sample tubes are held with said loader by frictional force.

11. A multiple sample blood collection device according to claim 8 wherein said manifold includes a blood flow divider opposite said second end of said venipuncture needle and centrally positioned within the stream of blood emerging from said venipuncture needle at a distance approximately ten times the internal diameter of said venipuncture needle.

12. A multiple sample blood collection device according to claim 11 wherein said blood flow divider is of generally conical shape.