Article of manufacture for the photodynamic therapy of dermal lesion
First Claim
1. An article of manufacture for photodynamic therapy of a dermal lesion located at a dermal treatment site on skin which skin includes the stratum corneum, comprising:
- cover means adapted for being sealed to the skin for covering and defining a dermal treatment site and for providing a chamber opposite the dermal treatment site;
transparent transport means containing hydration agent and at least one photopharmaceutical, said transport means residing in said chamber and for engaging the skin at the treatment site to cause said hydration agent to hydrate the stratum corneum at the dermal treatment site to enhance the passage therethrough of light and said photopharmaceutical; and
light delivery means mounted to and inside said cover and residing in said chamber for photoactivating said photopharmaceutical at said dermal treatment site to cause said photopharmaceutical to treat the dermal lesion.
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Accused Products
Abstract
An article of manufacture for photodynamic therapy of a dermal lesion located at a dermal treatment site on skin including the stratum corneum, transparent hydrogel for covering the dermal treatment site and containing hydration agent and photopharmaceutical, the transparent hydrogel couples the hydration agent to the stratum corneum to hydrate and soften the stratum corneum to enhance its optical transmissiveness to facilitate the transmission of light therethrough and to enhance its chemical transmissiveness to facilitate the transmission therethrough of the photopharmaceutical for treatment of the dermal lesion; and light delivery means are included for delivering light through the transparent hydrogel and the hydrated stratum corneum to photoactivate the photopharmaceutical to treat the dermal lesion.
329 Citations
9 Claims
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1. An article of manufacture for photodynamic therapy of a dermal lesion located at a dermal treatment site on skin which skin includes the stratum corneum, comprising:
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cover means adapted for being sealed to the skin for covering and defining a dermal treatment site and for providing a chamber opposite the dermal treatment site; transparent transport means containing hydration agent and at least one photopharmaceutical, said transport means residing in said chamber and for engaging the skin at the treatment site to cause said hydration agent to hydrate the stratum corneum at the dermal treatment site to enhance the passage therethrough of light and said photopharmaceutical; and light delivery means mounted to and inside said cover and residing in said chamber for photoactivating said photopharmaceutical at said dermal treatment site to cause said photopharmaceutical to treat the dermal lesion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An article of manufacture for photodynamic therapy of a dermal lesion located at a dermal treatment site on skin which skin includes the stratum corneum, comprising:
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cover means adapted for being sealed to the skin for covering and defining a dermal treatment site and for providing a chamber opposite the dermal treatment site; transparent coupling means contained in said chamber and for covering the dermal treatment site, said transparent coupling means containing at least one hydration agent and at least one photopharmaceutical, said transparent coupling means for coupling said hydration agent to the stratum corneum at the dermal treatment site to hydrate and soften the stratum corneum to enhance the optical transmissiveness of the stratum corneum to facilitate the transmission of light therethrough and to enhance its chemical transmissiveness to facilitate the transmission therethrough of said photopharmaceutical for treatment of the dermal lesion; and light delivery means mounted to and inside said cover and for delivering light through said transparent coupling means and through said hydrated stratum corneum to illuminate the dermal treatment site by light diffusion to photoactivate said photopharmaceutical at said dermal treatment site to treat the dermal lesion.
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Specification