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Medicinal adhesive for percutaneous administration

  • US 5,505,956 A
  • Filed: 04/01/1994
  • Issued: 04/09/1996
  • Est. Priority Date: 11/30/1992
  • Status: Expired due to Term
First Claim
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1. A transdermal skin patch to adhere to a patient'"'"'s skin, said skin patch comprising (1) a water-impermeable support or backing layer, (2) a liner, and between the two, (3) a multilayer laminate of from 2 to 5 adhesive layers, each of said adhesive layers comprising an oil-soluble drug, an adhesive resin, a penetration enhancer, a water-absorptive material and a lenitive agent, wherein each adhesive layer contains no water and has a different water absorption capacity in which the lowest layer which is to be contacted with the skin has the lowest water absorption capacity and the most upper layer in contact with the backing layer has the highest water absorption capacity, and the drug is ketoprofen present in an amount of 0.1 to 40% by weight.

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