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Insulin derivatives, a process for the preparation thereof, the use thereof, and a pharmaceutical formulation containing them

  • US 5,506,202 A
  • Filed: 05/16/1995
  • Issued: 04/09/1996
  • Est. Priority Date: 12/29/1988
  • Status: Expired due to Term
First Claim
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1. An essentially purified insulin derivative of the formula II ##STR8## or a physiologically tolerated salt thereof, wherein a) R30 and R31 together are OH;

  • orb) R30 is a residue of a neutral, genetically encodable L-amino acid, and R31 is OH or a physiologically acceptable organic group having 0 to 3 α

    -amino acids that are neutral or basic naturally occurring L-amino acids selected from the group consisting of Gly, Ala, Ser, Thr, Val, Leu, Ile, Asn, Gln, Cys, Met, Tyr, Phe, Pro, Hyp, Arg, Lys, Hyl, Orn, Cit, and His, provided that R30 is not Ala at the same time that R31 is OH, and further provided that the A- and B-chains are not the sequences of bovine insulin.

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