Semiconductor bio-electronic devices incorporating biochemical stabilization layers

• US 5,506,420 A
• Filed: 09/14/1994
• Issued: 04/09/1996
• Est. Priority Date: 09/14/1994
• Status: Expired due to Fees

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Hnatyszyn, H. James, Gelman, Andrew, Rajguru, Samir, Kossovsky, Nir
• Primary Examiner(s): Hille, Rolf
• Assistant Examiner(s): TRAN, MINH LOAN
• Application Number:
  US08/306,004
• Time in Patent Office: 573 Days
• Field of Search: 257/40, 257/52, 257/53, 257/442, 257/642, 257/643, 257/72
• US Class Current: 257/40
• CPC Class Codes: C12Q 1/001 Enzyme electrodes

Abstract

Improved bio-electronic devices in which a layer of a polyhydroxy oligomer is provided between the surface of a semiconductor material and an electronically active biochemical molecule which is designed to be bound to the semiconductor surface to provide an electronic device. The layer of polyhydroxy oligomer functions as a biochemical stabilization layer to prevent denaturization of the electronically active biochemical molecule.

Claims

1. A bio-electronic device comprising:

a semiconductor layer having a surface consisting essentially of a semiconductor material;

a biochemical stabilization layer consisting essentially of a polyhydroxy oligomer, said stabilization layer having a) an interior surface in contact with and bound to said semiconductor layer surface and b) an exterior surface;

a layer of electronically active biochemical molecules bound to said exterior surface of said biochemical stabilization layer to provide an electronically active biochemical layer having its own exterior surface.

2. A bio-electronic device according to claim 1 wherein said semiconductor material is selected from the group consisting of silicon, indium tin oxide, tin dioxide and silicon tin oxide.

3. A bio-electronic device according to claim 1 wherein said semiconductor material is an amorphous material selected from the group consisting of gallium arsenide, indium phosphide, cadmium telluride and cadmium sulfide.

4. A bio-electronic device according to claim 1 wherein said polyhydroxy oligomer is selected from the group of oligomers consisting of trehalose, maltose, cellobiose and zylotol.

5. A bio-electronic device according to claim 1 wherein said electronically active biochemical molecules are selected from the group consisting of electron donors and electron acceptors.

6. In a bio-electronic device wherein a layer of electronically active biochemical material is situated over the surface of a semiconductor layer and wherein the electronic activity of said biochemical material is reduced due to denaturization of said biochemical material upon binding to said surface, the improvement comprising:

reducing the denaturization of said electronically active biochemical material by providing a biochemical stabilization layer situated between said layer of electronically active biochemical material and the surface of said semiconductor layer, said biochemical stabilization layer consisting essentially of a polyhydroxy oligomer, said stabilization layer having an interior surface in contact with and bound to said semiconductor layer surface and an exterior surface onto which said electronically active biochemical material is bounded.

7. An improved bio-electronic device according to claim 6 wherein said semiconductor material is selected from the group consisting of silicon, indium tin oxide, tin dioxide and silicon tin oxide.

8. An improved bio-electronic device according to claim 6 wherein said semiconductor material is an amorphous material selected from the group consisting of gallium arsenide, indium phosphide, cadmium telluride and cadmium sulfide.

9. An improved bio-electronic device according to claim 6 wherein said polyhydroxy oligomer is selected from the group of oligomers consisting of trehalose, maltose, cellobiose and zylotol.

10. An improved bio-electronic device according to claim 6 wherein said electronically active biochemical molecule is selected from the group consisting of electron donors and electron acceptors.