Method and system for optimizing dialysis clearance
First Claim
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1. A method for obtaining the highest whole body dialysis clearance in a dialysis system comprising the steps of:
- varying a parameter that effects dialysis efficiency during part of a dialysis run;
measuring a metabolite concentration in an outflow dialysate;
developing a metabolite concentration profile as a function of the varied parameter from the metabolite concentration measurements; and
correlating the metabolite concentration measurements to determine an optimum parameter setting that yields a maximum metabolite concentration.
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Abstract
A system and method using same are provided for determining the optimum operating conditions of a dialysis process that yields the highest whole body dialysis clearance. The system varies a parameter that effects dialysis efficiency during part of a dialysis run. The system then measures a metabolite concentration in an outflow dialysate. The system develops a metabolite concentration profile as a function of the varied parameter. Based on these measurements, the system correlates the metabolite concentration measurements to determine the optimum parameter setting that yields the maximum metabolite concentration.
240 Citations
19 Claims
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1. A method for obtaining the highest whole body dialysis clearance in a dialysis system comprising the steps of:
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varying a parameter that effects dialysis efficiency during part of a dialysis run; measuring a metabolite concentration in an outflow dialysate; developing a metabolite concentration profile as a function of the varied parameter from the metabolite concentration measurements; and correlating the metabolite concentration measurements to determine an optimum parameter setting that yields a maximum metabolite concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for determining the optimum blood pump setting of a dialysis system to obtain the highest whole body dialysis clearance comprising the steps of:
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varying a blood flow rate during a dialysis run; measuring a metabolite concentration in an outflow dialysate; developing a metabolite concentration profile as a function of the blood flow rate; and correlating the metabolite concentration measurements to determine an optimum blood flow rate setting that yields a maximum metabolite concentration. - View Dependent Claims (9, 10, 11, 12, 13)
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14. A system for obtaining the highest whole body dialysis clearance in a dialysis system comprising:
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means for varying a parameter that effects dialysis efficiency during part of a dialysis run; means for measuring a metabolite concentration in an outflow dialysate; means for developing a metabolite concentration profile as a function of the varied parameter; and means for correlating the metabolite concentration measurements to determine an optimum parameter setting that yields a maximum metabolite concentration. - View Dependent Claims (15, 16, 17, 18, 19)
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Specification