Polymeric amorphous calcium phosphate compositions

• US 5,508,342 A
• Filed: 02/01/1994
• Issued: 04/16/1996
• Est. Priority Date: 02/01/1994
• Status: Expired due to Term

• Current Assignee: The United States of America As Represented By The Secretary of Commerce
• Original Assignee: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
• Inventors: Skrtic, Drago, Eanes, Edward D., Antonucci, Joseph M.
• Primary Examiner(s): Szekely, Peter A.
• Application Number:
  US08/189,708
• Time in Patent Office: 805 Days
• Field of Search: 523/115, 523/116, 523/118, 524/417, 524/788, 524/436
• US Class Current: 524/788
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61K 6/30 Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• CPC Class Codes: A61K 6/69 Medicaments
• CPC Class Codes: A61K 6/75 Apatite
• CPC Class Codes: A61K 6/76 comprising silicon-containing compounds
• CPC Class Codes: A61K 6/77 Glass
• CPC Class Codes: A61K 6/887 Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61K 6/891 Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: C08K 3/32 Phosphorus-containing compounds
• CPC Class Codes: C08L 31/04 Homopolymers or copolymers of vinyl acetate
• CPC Class Codes: C08L 33/06 of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
• CPC Class Codes: C08L 33/068 containing glycidyl groups
• CPC Class Codes: C08L 33/08 Homopolymers or copolymers of acrylic acid esters
• CPC Class Codes: C08L 33/10 Homopolymers or copolymers of methacrylic acid esters
• CPC Class Codes: C08L 33/14 of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
• CPC Class Codes: C08L 39/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C08L 43/04 Homopolymers or copolymers of monomers containing silicon
• CPC Class Codes: C08L 67/07 having terminal carbon-to-carbon unsaturated bonds
• CPC Class Codes: C08L 71/02 : Polyalkylene oxides

Abstract

A mineralizing composition for skeletal tissue comprising a mixture of an saturated monomer system, and a particulate mineralizing agent.

Claims

1. A mineralizing composition for skeletal tissue comprising a mixture of

an unsaturated monomer system, and

a particulate mineralizing agent comprising amorphous calcium phosphate.

2. A mineralizing composition according to claim 1 wherein said unsaturated monomer system comprises at least one monomer which, upon polymerization, forms a polymer of sufficient permeability to permit slow diffusion of water and mineralizing agent to effect highly crystalline mineralization at a skeletal tissue interface.

3. A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes at least one cross-linking agent.

4. A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes at least one monomer, the homopolymer of which is hydrophilic.

5. A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes at least one monomer, the homopolymer of which is hydrophilic and at least one cross-linking agent.

6. A mineralizing composition according to claim 2 wherein said at least one monomer includes a methacrylate moiety.

7. A mineralizing composition according to claim 4 wherein said at least one cross-linking agent comprises a methacrylate moiety.

8. A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes a free-radical initiator.

9. A mineralizing composition according to claim 8 wherein said free-radical initiator is a photoinitiator.

10. A mineralizing composition according to claim 1 wherein said composition further includes a stabilizing agent.

11. A mineralizing composition according to claim 10 wherein said stabilizing agent includes Mg ions.

12. A mineralizing composition according to claim 10 wherein said stabilizing agent includes CO₃ ions.

13. A mineralizing composition according to claim 10 wherein said stabilizing agent includes P₂ O₇ ions.

14. A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes 2, 2propane.

15. A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes triethyleneglycol dimethacrylate.

16. A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes 2-hydroxyethyl methacrylate.

17. A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes zirconyl dimethacrylate.

18. A mineralizing composition according to claim 9 wherein said photoinitiator is camphorquinone.

19. A mineralizing composition according to claim 8 further including a polymerization accelerator.

23. A mineralizing composition according to claim 1 wherein the mineralizing filler is pretreated or treated in situ in the composite paste with an appropriate surface-active agent selected from the group consisting of silane, titanate, zirconate and aluminate class of compounds or mixtures thereof.

20. A mineralizing composite for skeletal tissue comprising an inorganic particulate mineralizing agent which comprises amorphous calcium phosphate incorporated within a polymeric matrix.

21. A mineralizing composite according to claim 20 wherein said cross-linked polymeric matrix is of sufficient hydrophilicity to permit diffusion of water and ions therethrough.

22. A mineralizing composite according to claim 20 wherein said polymeric matrix is a cross-linked matrix.