Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values
First Claim
1. A method of drug delivery into a patient'"'"'s airway, comprising:
- simultaneously measuring a patient'"'"'s inspiratory flow rate and inspiratory volume;
determining whether the measured inspiratory flow rate and inspiratory volume equals a predetermined inspiratory flow rate and inspiratory volume; and
releasing an aerosolized drug responsive to said measured inspiratory flow rate and inspiratory volume being determined to be equal to said predetermined inspiratory flow rate and inspiratory volume into the patient'"'"'s inspiratory flow at substantially zero velocity at a point of release or at a velocity which reduces to substantially zero after travelling 2 cm or less from a point of release in the absence of the patient'"'"'s inspiration.
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Accused Products
Abstract
A method of drug delivery is disclosed wherein a patient'"'"'s inspiratory flow rate and inspiratory volume are simultaneously measured using a portable, hand-held, device which may be electronic and battery-powered or mechanical. Information obtained from the measurement is used to release, into a patient'"'"'s inspiratory flow path, particles of a pharmaceutically active drug. The released particles have a particle size in the range of from about 0.5 to 12 microns. The drug is released when the patient'"'"'s measured inspiratory flow rate is in the range of from about 0.10 to about 2.0 liters/second and the patient'"'"'s inspiratory volume is in the range of from about 0.15 to about 0.8 liters. By measuring inspiratory flow and volume and releasing within the specific parameters with respect to both flow and volume, it is possible to obtain a high degree of repeatability with respect to dosing of a patient and further to deliver a relatively high percentage of the released drug to the patient'"'"'s circulatory system.
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Citations
30 Claims
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1. A method of drug delivery into a patient'"'"'s airway, comprising:
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simultaneously measuring a patient'"'"'s inspiratory flow rate and inspiratory volume;
determining whether the measured inspiratory flow rate and inspiratory volume equals a predetermined inspiratory flow rate and inspiratory volume; andreleasing an aerosolized drug responsive to said measured inspiratory flow rate and inspiratory volume being determined to be equal to said predetermined inspiratory flow rate and inspiratory volume into the patient'"'"'s inspiratory flow at substantially zero velocity at a point of release or at a velocity which reduces to substantially zero after travelling 2 cm or less from a point of release in the absence of the patient'"'"'s inspiration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of drug delivery, comprising:
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simultaneously measuring a patient'"'"'s inspiratory flow rate and inspiratory volume with a portable, hand-held, battery-powered device; and releasing particles of a pharmaceutically active drug having a particle size in the range of from about 0.5 to 12 microns, the drug being released at a substantially zero rate of velocity relative to the patient'"'"'s inspiratory flow path and occurring when the patient'"'"'s measured inspiratory flow rate is in the range of from about 0.10 to 2.0 liters/second and the patient'"'"'s inspiratory volume is in the range of from about 0.15 to about 0.80 liters. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification