Enhancement of thrombolysis with external ultrasound

• US 5,509,896 A
• Filed: 09/09/1994
• Issued: 04/23/1996
• Est. Priority Date: 09/09/1994
• Status: Expired due to Term

• Current Assignee: TransOn LLC
• Original Assignee: Coraje, Inc.
• Inventors: Carter, Robert E.
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): KNIGHTS, LAIRD
• Application Number:
  US08/303,858
• Time in Patent Office: 592 Days
• Field of Search: 601/2, 604/21, 604/22, 604/27, 604/28, 604/52, 604/53, 606/127, 606/128
• US Class Current: 604/21
• CPC Class Codes: A61B 17/22004 using mechanical vibrations, e.g. ultrasonic shock waves A61B17/225 takes precedence
• CPC Class Codes: A61B 17/22012 in direct contact with, or very close to, the obstruction or concrement for removing obstructions in blood vessels by laser A61B18/245
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61B 2017/22088 ultrasound absorbing, drug activated by ultrasound
• CPC Class Codes: A61B 2017/22089 Gas-bubbles
• CPC Class Codes: A61B 2090/3925 ultrasonic
• CPC Class Codes: A61B 2090/3933 Liquid markers
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

Apparatus and methods are provided for enhancing the thrombolytic action of a thrombolytic agent and removing a thrombosis from a vascular system by introducing a select dose of thrombolytic agent proximate the thrombosis disposed within a vessel of a body and radiating the thrombosis with ultrasound generated exterior to the body to effect removal of the thrombosis in less time than the time required by activity of the selected dose of thrombolytic agent without the ultrasonic radiation of the thrombosis.

Claims

1. A method for enhancing thrombolytic action of a thrombolytic agent, said method comprising the steps of:

(a) injecting a thrombolytic agent proximate a thrombosis disposed in a vessel within a body; and

(b) directing ultrasonic energy, generated exterior to the body, at the thrombosis with proximate thrombolytic agent, of sufficient energy to increase the thrombolytic action of the thrombolytic agent, said ultrasonic energy being less than about 100 Kz at less than about 50 watts power.

2. The method according to claim 1 wherein streptokinase is injected as the thrombolytic agent at a concentration of less than about 2,000 u/ml.

3. The method according to claim 1 wherein streptokinase is injected as the thrombolytic agent at a concentration of about 250 u/ml.

4. The method according to claim 1 wherein streptokinase is injected, as the thrombolytic agent at a concentration of between about 50 u/ml and about 2000 u/ml.

5. The method according to claim 3 wherein said ultrasonic energy is directed with a frequency of about 26 kHz.

6. The method according to claim 4 wherein said ultrasonic energy is directed with a frequency of about 26 kHz.

7. Apparatus for removal of a cardiovascular blockage, said apparatus comprising, in combination:

means for introducing a thrombolytic agent proximate a cardiovascular blockage disposed in a vessel within a body; and

ultrasonic means for radiating the cardiovascular blockage with proximate thrombolytic agent with a frequency of less than about 100 kHz at less and 50 watts of power, said ultrasonic means being disposed exterior to the vessel and body.