Fixed tissue medical devices comprising albumin-binding dyes
First Claim
1. An implantable medical device comprising fixed tissue incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when said device is in contact with a physiological fluid containing albumin.
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Abstract
An implantable medical device is provided which comprises a fixed tissue incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when the device is in contact with a physiological fluid containing albumin. These albumin-binding dyes have been found to significantly reduce calcification when incorporated in tissue heart valves. A method of increasing the albumin-binding ability of an implantable medical device is also provided.
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Citations
32 Claims
- 1. An implantable medical device comprising fixed tissue incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when said device is in contact with a physiological fluid containing albumin.
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16. An implantable medical device comprising:
- a surface of fixed tissue and on the fixed tissue surface an amount of a conjugate comprising;
a. an albumin-binding dye and b. a physiologically-acceptable water-soluble polymer, wherein said amount of the conjugate is effective to bind albumin to the fixed tissue surface of said medical device. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
- a surface of fixed tissue and on the fixed tissue surface an amount of a conjugate comprising;
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29. A method of increasing the albumin-binding ability of a implantable medical device comprising fixed tissue, said method comprising the step of:
a. incorporating into said fixed tissue an amount of an albumin-binding dye;
wherein the amount of the albumin-binding dye is effective to form a coating of endogenous albumin on a surface of said fixed tissue when the surface is in contact with a physiological fluid containing albumin.- View Dependent Claims (30, 31, 32)
Specification