Antimicrobial interferon-inducing medicament

• US 5,510,387 A
• Filed: 07/13/1994
• Issued: 04/23/1996
• Est. Priority Date: 11/16/1992
• Status: Expired due to Fees

• Current Assignee: Nikolai Borisovich Leonidov
• Original Assignee: Nikolai Borisovich Leonidov
• Inventors: Seleznev, Nikolai G., Leonidov, Nikolai B.
• Primary Examiner(s): Cintins, Marianne
• Assistant Examiner(s): MACMILLAN, KEITH D
• Application Number:
  US08/256,494
• Time in Patent Office: 650 Days
• Field of Search: 514/603
• US Class Current: 514/603
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/505 Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• CPC Class Codes: A61K 31/63 Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

An antimicrobial and interferon-inducing composition containing the crystalline gamma-modification of para-amino benzenesulfanilamide and a method for inducing interferon by administering a composition containing crystalline gamma-modification of para-amino benzenesulfanilamide.

Claims

1. A method of inducing interferon comprising administering to a patient a composition comprising an effective amount of crystalline gamma-modification of para-aminobenzenesulfanilamide in a pharmaceutically acceptable diluent or carrier.

2. A method according to claim 1 wherein the crystalline gamma-modification of para-aminobenzene sulfanilamide is present in the composition in an amount of from 1.5 to 2.5 weight % and said composition is administered to the patient by injection.

3. A method according to claim 2 wherein the composition further comprises low molecular weight polyvinylpyrrolidone.

4. A method according to claim 3 wherein the low molecular weight polyvinylpyrrolidone is present in an amount of from 2.0 to 4.0 weight %.

5. A method according to claim 1 wherein the crystalline gamma-modification of para-aminobenzenesulfanilamide is administered in a rectal suppository.

6. A method according to claim 5 wherein the crystalline gamma-modification of para-aminobenzenesulfanilamide in the suppository is present in an amount of from 12.5 to 17.5 weight %.

7. A method for inducing interferon according to claim 1 comprising applying topically a composition comprising the crystalline gamma-modification of para-aminobenzene sulfanilamide and 2,4-dioxo-6-methyl-1,2,3,4-tetrahydropyrimidine.