Apparatus for testing pipetting needle linearity in an automated analyzer

• US 5,512,247 A
• Filed: 04/11/1995
• Issued: 04/30/1996
• Est. Priority Date: 05/02/1994
• Status: Expired due to Term

• Current Assignee: Roche Diagnostics Corporation (Roche Holding AG)
• Original Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Inventors: Caratsch, Thomas, Bonacina, Guido, Moser, Rolf
• Primary Examiner(s): Snay, Jeffrey R.
• Assistant Examiner(s): CARRILLO, BIBI SHARIDAN
• Application Number:
  US08/420,279
• Time in Patent Office: 385 Days
• Field of Search: 324/519, 324/661, 324/758, 422/82.01, 422/63, 422/64, 422/67, 422/100, 422/82.02, 436/49, 201/401
• US Class Current: 422/67
• CPC Class Codes: G01B 7/282 for measuring roundness
• CPC Class Codes: G01N 2035/1013 Confirming presence of tip
• CPC Class Codes: G01N 35/10 Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices G01N35/0099 takes precedence
• CPC Class Codes: Y10T 436/114998 with treatment or replacement of aspirator element [e.g., cleaning, etc.]

Abstract

An analyzer has a horizontally disposed baseplate on which primary containers and secondary containers are disposed, a pipetting needle, a transport device, and a control device. The pipetting needle is formed of an electrically conductive material and is connected to a metering device by a tubing, and is for transferring a predetermined volume of liquid each time from a primary container to a secondary container. The transport device is for the controlled transport of the pipetting needle in three directions at right angles to one another, two of the transport directions extending horizontally and the third transport direction extending vertically. The control device is for controlling the metering device and the transport device. For the purpose of testing the linearity of the pipetting needle the analyzer includes a device for guiding the tip of the pipetting needle around the periphery of the top edge of a reference body (the tip of the pipetting needle is guided at a specific distance from the top edge of the reference body, which distance is a measure of the acceptable curvature of the pipetting needle), and an electrical circuit for detecting electrical contact between the tip of the pipetting needle and the reference body.

Claims

1. An analyzer comprising:

a) a horizontally disposed baseplate on which primary containers and secondary containers are disposed;

b) a metering device for measuring a predetermined volume of a liquid;

c) a pipetting needle for transferring a predetermined volume of liquid from a primary container to a secondary container, the pipetting needle being formed of an electrically conductive material and being connected by tubing to the metering device;

d) a transport device for the controlled transport of the pipetting needle in three directions at right angles to one another, two of the transport directions extending horizontally and the third transport direction extending vertically;

e) an electrically conductive reference body having a top edge and being positioned at a predetermined location with respect to the analyzer; and

f) a control device for controlling the metering device and the transport device, the control device comprising;

1) means for guiding the tip of the pipetting needle around the the external periphery of the top edge of the reference body, the tip of the pipetting needle being guided at a specific distance from the top edge of the reference body, the distance being a measure of the acceptable curvature of the pipetting needle, and

2) an electrical circuit between the pipetting needle and the reference body for detecting an electrical contact between the tip of the pipetting needle and the reference body.

2. The analyzer according to claim 1, wherein the electrically conductive reference body is rigidly connected to the baseplate, and in each of the horizontal transport directions has two outer surfaces disposed perpendicularly to the transport direction.

3. The analyzer of claim 2 further comprising means for determining the coordinates of a reference position of the pipetting needle in at least one of the horizontal transport directions, the means being adapted to move the transport device of the pipetting needle causing the pipetting needle to be moved in opposite directions in each case to a position near each of the two outer surfaces of the reference body which are disposed perpendicularly to the transport direction, the pipetting needle being moved in each case towards a surface of the reference body until the value of the electrical capacitance between the pipetting needle and the reference body, as measured by a circuit, reaches a predetermined value corresponding to a specific distance between the pipetting needle and the surface of the reference body.

4. The analyzer according to claim 1, wherein the reference body is in the form of a parallelopiped.

5. The analyzer according to claim 1, wherein the top edge of the reference body is shaped as a square.