Smoking substitute

• US 5,512,306 A
• Filed: 11/07/1994
• Issued: 04/30/1996
• Est. Priority Date: 06/19/1992
• Status: Expired due to Term

• Current Assignee: McNeil AB (Johnson & Johnson)
• Original Assignee: Pharmiva AB
• Inventors: Andersson, Sven B., Carlsson, Thommy
• Primary Examiner(s): HUNTER, JEANETTE M
• Application Number:
  US08/335,175
• Time in Patent Office: 540 Days
• Field of Search: 426/3-6, 426/650, 131/1, 131/2, 131/359, 131/369, 131/366, 131/367
• US Class Current: 426/3
• CPC Class Codes: A23G 3/368 containing vitamins, antibiotics
• CPC Class Codes: A23G 4/06 characterised by the composition containing organic or inorganic compounds
• CPC Class Codes: A23G 4/126 containing vitamins, antibiotics
• CPC Class Codes: A24B 15/16 of tobacco substitutes
• CPC Class Codes: A61K 47/6951 using cyclodextrin cyclodextrins used as simple excipients A61K47/40
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61K 9/2077 Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present invention concerns a smoking substitute composition wherein nicotine is the form of an inclusion complex between nicotine and a cyclodextrincompound.

Claims

1. A smoking substitute composition for application to the nose or oral cavity, comprising an inclusion complex of nicotine and a cyclized polysaccharide and an excipient acceptable for pharmaceutical use or as a food additive.

2. The composition of claim 1, wherein said cyclized polysaccharide is a cyclodextrin.

3. The composition of claim 9, wherein said cyclodextrin is selected from the group consisting of alphacyclodextrin, gamma-cyclodextrin, beta-cyclodextrin, and derivatives thereof.

4. The composition of claim 3, wherein said cyclodextrine is beta-cyclodextrin.

5. The composition of claim 1 for sublingual or buccal administration, wherein the excipient is a direct compressible, water soluble substance.

6. The composition of claim 1, wherein said excipient is selected from the group consisting of lactose, sorbitol, mannitol, and non-complexed cyclodextrin.

7. The composition of claim 1, further comprising a lubricant.

8. The composition of claim 7, wherein said lubricant is magnesium stearate.

9. The composition of claim 1, in the form of a spray for nasal administration.

10. The composition of claim 1, in the form of a powder.

11. The composition of claim 1, in the form of a tablet.

12. The composition of claim 1, wherein the composition is dispersed in a chewing gum matrix.

13. A composition comprising:

(1) an inclusion complex of nicotine and cyclodextrin, wherein said inclusion complex comprises from about 0.1% w/w to about 10% w/w of said composition;

(2) about 0.5% w/w to about 3% w/w of a lubricant; and

(3) an excipient selected from the group consisting of lactose, non-complexed cyclodextrin, sorbitol, and mannitol.