Curdlan sulfate

• US 5,512,672 A
• Filed: 06/14/1993
• Issued: 04/30/1996
• Est. Priority Date: 07/07/1988
• Status: Expired due to Term

• Current Assignee: Ajinomoto Co., Inc., Fujirebio Inc. (H.U. Group Holdings, Inc.)
• Original Assignee: Ajinomoto Co., Inc., Fujirebio Inc. (H.U. Group Holdings, Inc.)
• Inventors: Yamamoto, Naoki, Nakashima, Hideki, Matsuzaki, Kei, Mimura, Toru, Yoshida, Takashi, Kaneko, Yutaro, Uryu, Toshiyuki
• Primary Examiner(s): Robinson, Douglas W.
• Assistant Examiner(s): Kunz, Gary L.
• Application Number:
  US08/076,174
• Time in Patent Office: 1,051 Days
• Field of Search: 536/20, 536/21, 536/51, 536/54, 536/112, 536/118, 536/122, 514/54-55, 514/59-60, 514/885
• US Class Current: 536/118
• CPC Class Codes: C08B 37/0024 beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof

Abstract

A beta-1,3-glucan of sulfated curdlan having a sulfur content of 12.4 to 17% and an average molecular weight of 27,000 to 330,000 daltons. Sulfate curdlan exhibits strong HIV inhibitory activity with little anticoagulant activity and little toxicity.

Claims

1. A β

-1,3-glucan of a sulfated curdlan having a sulfur content of about 12.4 to 17%, and an average molecular weight by gel filtration of from about 27.000 to 330,000.

2. The low molecular weight β

-1,3glucan of claim 1, having a sulfur content of 14.4%, and a molecular weight of about 113,000.