Partial body plethysmograph for measuring human respiratory system impedance

• US 5,513,648 A
• Filed: 02/28/1994
• Issued: 05/07/1996
• Est. Priority Date: 02/28/1994
• Status: Expired due to Fees

• Current Assignee: Trustees of Boston University
• Original Assignee: Trustees of Boston University
• Inventors: Jackson, Andrew C.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): HUANG, STEPHEN D
• Application Number:
  US08/202,660
• Time in Patent Office: 799 Days
• Field of Search: 128/721, 128/713, 128/734, 128/720, 128/716, 128/693, 128/719, 128/633, 128/724, 128/686, 128/688, 128/719, 128/713, 128/720, 128/721, 128/729, 128/693, 600/21, 248/393, 248/229, 297/313
• US Class Current: 600/529
• CPC Class Codes: A61B 5/0806 by whole-body plethysmography measuring blood flow using plethysmography A61B5/0295; impedance plethysmography A61B5/053; measuring volume of the body or parts thereof A61B5/1073

Abstract

A partial body plethysmograph is provided to enable accurate modeling of a human'"'"'s respiratory system for input frequencies of up to about 96 Hz using transfer impedance measurements. One preferred embodiment comprises a container for sealingly enclosing a portion of the subject'"'"'s body, a pressure source for generating pressure signals over a predetermined frequency range, an air flow sensor for measuring the flow of air supplied to the subject, a pressure sensor for measuring the pressure applied to the cavity of the subject and a processor for controlling the pressure source, for storing the measured air flow and pressure and for determining the respiratory system impedance of the subject. An eight element model is used by the processor to inversely model the transfer impedance data and thereby determined characteristics of the respiratory system of the subject.

Claims

1. An apparatus for analyzing a respiratory system of a subject, having a body, a neck, legs, and a respiratory system impedance and being supplied with a flow of air, comprising:

a container for enclosing a portion of the subject'"'"'s body, said container comprising a chamber portion and a neck opening for the subject'"'"'s neck, whereby a pressure is applied to the portion of the subject'"'"'s body enclosed in the chamber;

a pressure source for generating pressure signals within the container over a predetermined frequency range, wherein the pressure signals vary the pressure applied to the portion of the subject enclosed in the chamber and comprises pseudo random noise signals having frequency components from about 0.1 Hz to about 128 Hz in about 2 Hz increments;

an air flow sensor for measuring the flow of air supplied to the subject and providing a measured air flow value;

a pressure sensor for measuring the pressure applied to the portion of the subject'"'"'s body enclosed within said container and providing a measured pressure value; and

a processor connected to said air flow sensor, said pressure sensor and said pressure source, said processor operative to control said pressure source, store the measured air flow value and the measured pressure value, determine the respiratory system impedance of the subject using the measured air flow value and the measured pressure value and generate an eight element model of the subject'"'"'s respiratory system by inversely modeling the respiratory system impedance.

2. The apparatus of claim 1 wherein said air flow sensor comprises a differential pressure transducer.

3. The apparatus of claim 1 wherein said pressure sensor comprises a pressure transducer.

4. The apparatus of claim 1 wherein the subject'"'"'s respiratory system comprises central airways, peripheral airways, lumped bronchial airway walls and tissue, wherein the subject has an alveolar gas compression value associated therewith, wherein the central airways have a resistance and an inertance associated therewith, wherein the peripheral airways have a resistance associated therewith, wherein the lumped bronchial airway walls have a compliance associated therewith, wherein the tissue has a resistance, an inertance and a capacitance associated therewith and wherein said eight element model comprises:

a resistance corresponding to the resistance of the central airways of the subject;

an inductance corresponding to the inertance of the central airways of the subject;

a resistance corresponding to the resistance of the peripheral airways of the subject;

a capacitance corresponding to the compliance of the lumped bronchial airway walls of the subject having one terminal connected to ground;

a capacitance corresponding to the alveolar gas compression value of the subject;

a resistance corresponding to the resistance of the tissue of the subject;

an inductance corresponding to the inertance of the tissue of the subject; and

a capacitance corresponding to the compliance of the tissue of the subject.

5. The apparatus of claim 1 further comprising a processor for inversely modeling the respiratory system impedance using data collected at frequencies from about 0.1 Hz to about 96 Hz.

6. The apparatus of claim 1 further comprising:

braces connected to said container for reducing vibration of said container caused by the pressure source signals; and

sealing means for sealing said container around the subject'"'"'s neck.

7. The apparatus of claim 1 wherein said container comprises a seat portion, three wall portions, a door portion, a plurality of seat brackets and a top portion, wherein said seat portion rests on at least two of said seat brackets and wherein said seat portion and said top portion are separated by a distance which may be adjusted by resting said seat portion on different seat brackets.

8. The apparatus of claim 7 wherein said top portion and said seat portion are angularly disposed with respect to each other.

9. The apparatus of claim 1 wherein said container further comprising at least one leg opening for the subject'"'"'s legs and sealing means for sealing said container around the subject'"'"'s legs.

10. A method of evaluating a respiratory system of a subject, having a body, a neck, legs, and a respiratory system impedance and being supplied with a flow of aft, comprising the steps of:

enclosing a portion of the subject'"'"'s body within a container, whereby an air pressure is applied to the portion of the subject enclosed in the chamber and wherein the portion comprises the subject'"'"'s body below the subject'"'"'s neck;

applying pressure signals to the subject within the container, wherein the pressure signals vary the air pressure applied to the portion of the subject enclosed in the chamber;

measuring the flow of air supplied to the subject;

measuring the air pressure within the container;

determining respiratory system impedance data for the subject using the measured air flow and air pressure; and

inversely modeling the respiratory system impedance data into an eight element model using data for input frequencies from about 0.1 Hz to about 9.6 Hz.

11. The method of claim 10 further comprising the step of enclosing the subject'"'"'s body above the subject'"'"'s legs within the container.

12. The method of claim 10 further comprising the step of comparing each element of said eight element model with predetermined respiratory system data.

13. The method of claim 10 further comprising the step of stabilizing the container with braces.

14. The method of claim 10 wherein the subject'"'"'s respiratory system comprises central airways, peripheral airways, lumped bronchial airway walls and tissue, wherein the subject has an alveolar gas compression value associated therewith, wherein the central airways have a resistance and an inertance associated therewith, wherein the peripheral airways have a resistance associated therewith, wherein the lumped bronchial airway walls have a compliance associated therewith, wherein the tissue has a resistance, an inertance and a capacitance associated therewith and wherein said eight element model comprises:

a resistance corresponding to the resistance of the central airways of the subject;

an inductance corresponding to the inertance of the central airways of the subject;

a resistance corresponding to the resistance of the peripheral airways of the subject;

a capacitance corresponding to the compliance of the lumped bronchial airway walls of the subject having one terminal connected to ground;

a capacitance corresponding to the alveolar gas compression of the subject;

a resistance corresponding to the resistance of the tissue of the subject;

an inductance corresponding to the inertance of the tissue of the subject; and

a capacitance corresponding to the compliance of the tissue of the subject.

15. A method of evaluating a subject, having a body, a neck, legs, and a respiratory system impedance and being supplied with a flow of air, comprising the steps of:

enclosing a portion of the subject'"'"'s body within a container, said container comprising a chamber portion and a neck opening for the subject'"'"'s neck whereby an air pressure is applied to the portion of the subject enclosed in the chamber and wherein the portion comprises the subject'"'"'s body below the subject'"'"'s neck;

applying pressure signals to the subject within the container, using at least two speakers wherein the pressure signals vary the pressure applied to the portion of the subject enclosed in the chamber;

measuring the flow of air supplied to the subject;

measuring the air pressure within the container;

determining respiratory system impedance data for the subject using the measured air flow and air pressure; and

inversely modeling the respiratory system impedance data into an eight element model.

16. A method of evaluating a respiratory system of a subject, having a body, a neck, legs, and a respiratory system impedance and being supplied with a flow of air, comprising the steps of:

enclosing a portion of the subject'"'"'s body within a container, said container comprising a chamber portion and a neck opening for the subject'"'"'s neck whereby an air pressure is applied to the portion of the subject enclosed in the chamber and wherein the portion comprises the subject'"'"'s body below the subject'"'"'s neck;

applying pressure signals to the subject within the container wherein the pressure signals vary the air pressure applied to the portion of the subject enclosed in the chamber and wherein the pressure signals comprise pseudo random noise signals having frequency components from about 0.1 Hz to about 128 Hz in about 2 Hz increments;

measuring the flow of air supplied to the subject;

measuring the air pressure within the container;

determining respirator system impedance data for the subject using the measured air flow and air pressure; and

inversely modeling the respiratory system impedance data into an eight element model.

17. An apparatus for analyzing a respiratory system of a subject, having a body, a neck, legs, and a respiratory system impedance and being supplied with a flow of air, comprising:

a container for enclosing a portion of the subject'"'"'s body, said container comprising a chamber portion and a neck opening for the subject'"'"'s neck, whereby a pressure is applied to the portion of the subject'"'"'s body enclosed in the chamber;

a pressure source comprising at least two speakers for generating pressure signals within the container over a predetermined frequency range, wherein the pressure signals vary the pressure applied to the portion of the subject enclosed in the chamber;

an air flow sensor for measuring the flow of air supplied to the subject and providing a measured air flow value;

a pressure sensor for measuring the pressure applied to the portion of the subject'"'"'s body enclosed within said container and providing a measured pressure value and

a processor connected to said air flow sensor, said pressure sensor and said pressure source, said processor operative to control said pressure source, store the measured air flow value and the measured pressure value, determine the respiratory system impedance of the subject using the measured air flow value and the measured pressure value and generate an eight element model of the subject'"'"'s respiratory system by inversely modeling the respiratory system impedance.

18. The apparatus of claim 17 further comprising a processor for inversely modeling the respiratory system impedance using data collected at frequencies from about 0.1 Hz to about 96 Hz.