Closed drug delivery system
First Claim
Patent Images
1. A mixing apparatus comprising:
- (a) a container assembly including;
(i) a container having a fluid inlet passageway, a fluid outlet passageway and walls defining an internal chamber in communication with said fluid inlet and outlet;
(ii) adding means disposed within said chamber for adding an additive to fluid flowing through said chamber, said adding means comprising an additive and an additive presentation means for presenting said additive to the fluid;
(b) a dispensing device comprising a housing having a fluid inlet port and first and second portions, said housing including a covering adapted to retard oxygen, carbon dioxide and moisture permeation, said first portion including coupling means for coupling said container assembly with said first portion of said housing, said coupling means having a flow passageway adapted to communicate with said fluid inlet passageway of said container;
said second portion comprising;
(i) a base adapted to retard oxygen, carbon dioxide and moisture penetration, said base having a fluid outlet in communication with said flow passageway of said coupling means; and
(ii) a stored energy means cooperating with said base to define a reservoir containing a fluid, said reservoir being in communication with said fluid inlet port and said fluid outlet of said base, said stored energy means being acted upon by fluid introduced into said reservoir under pressure to move it from a starting configuration to an operative configuration wherein it will have a tendency to return toward its starting configuration causing fluid contained within said reservoir to flow out said fluid outlet of said base and into said flow passageway of said coupling means in a direction toward said adding means.
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Abstract
An apparatus for controllably intermixing two or more components in a sterile, closed environment to produce a flowable substance and then for expelling the flowable substance from the apparatus at a precisely controlled rate. The apparatus is particularly useful for medical applications and includes a dispenser portion with its own stored energy member for dispensing the flowable mixture and a coupling mechanism for coupling a drug vial to the dispenser portion for the controlled mixing of a medicament contained within the drug vial with a diluent stored within the dispenser portion of the apparatus via a sterile pathway.
135 Citations
29 Claims
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1. A mixing apparatus comprising:
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(a) a container assembly including; (i) a container having a fluid inlet passageway, a fluid outlet passageway and walls defining an internal chamber in communication with said fluid inlet and outlet; (ii) adding means disposed within said chamber for adding an additive to fluid flowing through said chamber, said adding means comprising an additive and an additive presentation means for presenting said additive to the fluid; (b) a dispensing device comprising a housing having a fluid inlet port and first and second portions, said housing including a covering adapted to retard oxygen, carbon dioxide and moisture permeation, said first portion including coupling means for coupling said container assembly with said first portion of said housing, said coupling means having a flow passageway adapted to communicate with said fluid inlet passageway of said container; said second portion comprising; (i) a base adapted to retard oxygen, carbon dioxide and moisture penetration, said base having a fluid outlet in communication with said flow passageway of said coupling means; and (ii) a stored energy means cooperating with said base to define a reservoir containing a fluid, said reservoir being in communication with said fluid inlet port and said fluid outlet of said base, said stored energy means being acted upon by fluid introduced into said reservoir under pressure to move it from a starting configuration to an operative configuration wherein it will have a tendency to return toward its starting configuration causing fluid contained within said reservoir to flow out said fluid outlet of said base and into said flow passageway of said coupling means in a direction toward said adding means. - View Dependent Claims (2, 3, 4, 5)
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6. A mixing apparatus comprising:
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(a) a container assembly including; (i) a container having a fluid inlet passageway, a fluid outlet passageway and walls defining an internal chamber in communication with said fluid inlet and outlet; (ii) adding means disposed within said chamber for adding an additive to fluid flowing through said chamber, said adding means comprising an additive and an additive presentation means for presenting said additive to the fluid; (b) a dispensing device comprising a housing having a fluid inlet port and first and second portions, said first portion including coupling means coupling said container assembly with said first portion of said housing, said coupling means having a flow passageway adapted to communicate with said fluid inlet passageway of said container; said second portion comprising; (i) a base having a fluid outlet in communication with said flow passageway of said coupling means; and (ii) a stored energy means cooperating with said base to define a reservoir for containing a fluid, said reservoir being in communication with said fluid inlet port and said fluid outlet of said base, said stored energy means being acted upon by fluid introduced into said reservoir under pressure to move it from a starting configuration to an operative configuration wherein it will have a tendency to return toward its starting configuration causing fluid contained within said reservoir to flow out said fluid outlet of said base and into said flow passageway of said coupling means in a direction toward said adding means. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13)
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14. A fluid mixing and infusion device
(a) a container assembly including: -
(i) a container having a fluid inlet passageway, a fluid outlet passageway and walls defining an internal chamber in communication with said fluid inlet and outlet; (ii) adding means disposed within said chamber for adding an additive to fluid flowing through said chamber, said adding means comprising an additive and an additive presentation means for presenting said additive to the fluid; (b) a dispensing device comprising a housing having a fluid inlet port and first and second portions, said first portion including coupling means coupling said container assembly with said first portion of said housing, said coupling means having a flow passageway adapted to communicate with said fluid inlet passageway of said container; said second portion comprising; (i) a base having a fluid outlet in communication with said flow passageway of said coupling means; and (ii) a thin, generally planar distendable membrane constructed of an elastic material, said membrane being adapted to overlay said base and cooperate therewith to define a reservoir for containing a fluid, said reservoir being in communication with said fluid inlet port and said fluid outlet of said base, said membrane being distendable by fluid introduced into said reservoir under pressure and having a tendency to return to a substantially less distended configuration, whereby the fluid contained within said reservoir will be urged to flow out said fluid outlet of said base and into said flow passageway of said coupling means in a direction toward said adding means. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A mixing apparatus comprising:
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(a) a container assembly including; (i) a container having a fluid inlet passageway, a fluid outlet passageway and walls defining an internal chamber in communication with said fluid inlet and outlet; (ii) adding means disposed within said chamber for adding an additive to fluid flowing through said chamber, said adding means comprising an additive and an additive presentation means for presenting said additive to the fluid; (b) a dispensing device comprising a housing having a fluid inlet port and first and second portions, said first portion including coupling means coupling said container assembly with said first portion of said housing, said coupling means having a flow passageway adapted to communicate with said fluid inlet passageway of said container; said second portion comprising; (i) a base having a fluid outlet in communication with said flow passageway of said coupling means; and (ii) a deformable barrier member said member being adapted to overlay said base and cooperate therewith to define a reservoir for containing a fluid, said reservoir being in communication with said fluid inlet port and said fluid outlet port of said base, said barrier member being movable from first position to a second position in response to fluid being introduced into said reservoir through said fluid inlet port; (c) an expandable member disposed in contact with said deformable barrier member, said expandable member being movable by said barrier member from a starting configuration to a second operative configuration wherein it will have a tendency to return toward its starting configuration causing fluid contained within said reservoir to flow out said fluid outlet of said base and into said flow passageway of said coupling means in a direction toward said adding means. - View Dependent Claims (25, 26, 27, 28, 29)
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Specification