Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines

• US 5,514,539 A
• Filed: 06/29/1993
• Issued: 05/07/1996
• Est. Priority Date: 06/29/1993
• Status: Expired due to Term

• Current Assignee: United States Department Of Health And Human Services (Government of the United States of America)
• Original Assignee: United States Department Of Health And Human Services (Government of the United States of America)
• Inventors: Bukh, Jens, Miller, Roger H., Purcell, Robert H.
• Primary Examiner(s): Jones, W. Gary
• Assistant Examiner(s): Sisson, Bradley L.
• Application Number:
  US08/086,428
• Time in Patent Office: 1,043 Days
• Field of Search: 435/5, 435/6, 435/91.1, 435/91.2, 435/810, 435/183, 536/23.1, 536/23.72, 536/24.32, 536/24.33, 536/25.3, 935/77, 935/78, 935/1-5
• US Class Current: 435/5
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: C07K 14/005 from viruses
• CPC Class Codes: C12N 2770/24222 New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
• CPC Class Codes: C12Q 1/707 non-A, non-B Hepatitis, excluding hepatitis D
• CPC Class Codes: Y10S 435/81 Packaged device or kit
• CPC Class Codes: Y10S 530/826 Viruses
• CPC Class Codes: Y10S 977/802 Virus-based particle

Abstract

The nucleotide and deduced amino acid sequences of 51 cDNAs are disclosed where each cDNA encodes the envelope 1 gene of an isolate of hepatitis C virus (HCV). The invention relates to the oligonucleotides, peptides and recombinant envelope 1 proteins derived from these sequences and their use in diagnostic methods and vaccines.

Claims