Insulin analogs modified at position 29 of the B chain
First Claim
Patent Images
1. An insulin analog of the formula ##STR11## or a pharmaceutically acceptable salt thereof, wherein A21 is Asn, or Ala;
- B1 is Phe, or is absent;
B2 is Val, or is absent;
B10 is His, or Asp;
B28 is any amino acid;
B29 is L-Pro, D-Pro, L-hydroxyproline, D-hydroxyproline;
and,B30 is Thr, Ala, or is absent.
1 Assignment
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Accused Products
Abstract
Analogs of human insulin modified at position 29 of the B chain thereof and, optionally, at other positions, have modified physico-chemical and pharmacokinetic properties and are useful in the treatment of hyperglycemia.
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Citations
81 Claims
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1. An insulin analog of the formula ##STR11## or a pharmaceutically acceptable salt thereof, wherein A21 is Asn, or Ala;
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B1 is Phe, or is absent; B2 is Val, or is absent; B10 is His, or Asp; B28 is any amino acid; B29 is L-Pro, D-Pro, L-hydroxyproline, D-hydroxyproline; and, B30 is Thr, Ala, or is absent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81)
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11. An insulin analog of the formula ##STR12##
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38. A method of treating hyperglycemia which comprises administering, to a patient in need thereof, an effective amount of an insulin analog of the formula ##STR13##
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65. A pharmaceutical composition which comprises an insulin analog of the formula ##STR14## in combination with a pharmaceutically acceptable carrier, diluent, or excipient.
Specification