Myocardial infarction and ischemia detection method and apparatus

• US 5,515,859 A
• Filed: 08/24/1993
• Issued: 05/14/1996
• Est. Priority Date: 08/24/1993
• Status: Expired due to Term

• Current Assignee: Colorado Health Care Research Corp.
• Original Assignee: Colorado Health Care Research Corp.
• Inventors: Paz, Frederick M.
• Primary Examiner(s): ZELE, KRISTA MICHELLE
• Application Number:
  US08/111,972
• Time in Patent Office: 994 Days
• Field of Search: 128/653.1, 128/719, 128/730, 128/633, 128/664, 250/340, 250/341, 250/343, 250/345, 250/341.1, 250/341.5, 250/341.8, 250/339.01, 422/84
• US Class Current: 250/339.13
• CPC Class Codes: A61B 5/083 Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
• CPC Class Codes: A61B 5/0873 using optical means
• CPC Class Codes: G01N 21/3504 for analysing gases, e.g. multi-gas analysis

Abstract

A device (10) for detecting a substance in a patient'"'"'s expired breath (88) such as adenosine indicative of cardiovascular distress. The device (10) shines an infrared light (68) through a chamber (14) containing the breath (88) to a detector (26). The detector (26) measures the intensity of the light (68) at selected frequency corresponding to absorption bands of the substance. Multiple photodetectors (112, 114, 116, 118) at different absorption band frequencies increase the specificity of detection. A reference chamber (16) containing a reference gas and coupled to an infrared photodetector (118) may be used to provide a baseline reference for a quantitative analysis.

Claims

1. A device for detecting adenosine in a patient'"'"'s expired breath indicative of cardiovascular distress, comprising:

a sample chamber adapted to receive and contain the patient'"'"'s expired breath;

a light source positioned to shine a light into the sample chamber;

a first light detector positioned to detect the light at a first predetermined frequency after it has traversed the sample chamber, the first light detector providing a first signal corresponding to the intensity of the light detected at said first predetermined frequency, where the first predetermined frequency corresponds to a first absorption band of adenosine; and

indicator means, responsive to the first signal, for providing an indication of the value of the first signal.

2. The device of claim 1, wherein said light source shines infrared light.

3. The device of claim 2, further comprising a second light detector positioned to detect the light at a second predetermined frequency after it has traversed the sample chamber, the second light detector providing a second signal corresponding to the intensity of the light detected at said second predetermined frequency, where the second predetermined frequency corresponds to a second absorption band of adenosine.

4. The device of claim 3, wherein at least one of said light detectors comprises an optical bandpass filter and a photodetector arranged such that the light travels through said optical bandpass filter before striking said photodetector.

5. The device of claim 4, wherein said optical bandpass filter has a center frequency of 1300 cm^-1 wavenumbers which corresponds to an absorption band of adenosine.

6. The device of claim 4, wherein said optical bandpass filter has a center frequency of 1580 cm^-1 wavenumbers which corresponds to an absorption band of adenosine.

7. The device of claim 4, wherein said optical bandpass filter has a center frequency of 1610 cm^-1 wavenumbers which corresponds to an absorption band of adenosine.

8. The device of claim 4, wherein said optical bandpass filter has a center frequency of 2880 cm^-1 wavenumbers which corresponds to an absorption band of adenosine.

9. The device of claim 1, further comprising a reference chamber to receive and contain a reference gas, wherein said light source is positioned to shine said light into said reference chamber, and further comprising a reference light detector positioned to detect said light at said first predetermined frequency after it has traversed said reference chamber, said reference light detector providing a reference signal corresponding to an intensity of said light detected at the first predetermined frequency and wherein said indicator means comprises means responsive to the reference signal for providing an indication of the difference between the value of the first signal and the value of the reference signal.

10. A method for detecting adenosine in a patient'"'"'s expired breath indicative of cardiovascular distress, the method comprising:

containing the breath;

shining a light through the breath;

detecting the light after it has passed though the breath;

providing a first signal corresponding to an intensity of the light detected at a first predetermined frequency, where the first predetermined frequency corresponds to a first absorption band of adenosine; and

indicating the value of the signal.

11. The method of claim 10, wherein the shining step includes shining light in the infrared range.

12. The method of claim 10, further comprising providing a signal corresponding to the intensity of the light detected at a second predetermined frequency, where the second predetermined frequency corresponds to a second absorption band of adenosine.

13. The method of claim 10 further including providing a reference signal and comparing the reference signal to the first signal.

14. A device for detecting adenosine in a patient'"'"'s expired breath indicative of cardiovascular distress, comprising:

a sample chamber to receive and contain the breath;

means for analyzing the breath contained within said sample chamber for the existence of the adenosine; and

display mean operatively coupled to said analyzing means to provide an output correlative to the existence of the adenosine.

15. The device of claim 14 further comprising means to initialize said device including reference means for receiving an exemplar having initializing qualities,

said reference means coupled to said analyzing means and

comparing means coupled to said analyzing means to receive data therefrom whereby said device will have been initialized.

16. The device of claim 15 wherein said analyzing means includes plural sensors, each said sensor tuned to a different characteristic of adenosine to render less likely a false positive reading.

17. The device of claim 16 further including means to sense the initiation of said detector including a flow meter coupled both to said sample chamber and a central processor control unit, whereby said device is enabled when breath expired by the patient triggers said flow meter to actuate said central processor control unit.

18. A method for diagnosing cardiovascular distress, the steps including:

sampling expired breath;

analyzing the breath for adenosine; and

displaying results of the analyzing step.

19. A method for diagnosing cardiovascular distress, the steps including:

sampling expired breath;

analyzing the breath for a telltale correlative of the distress; and

displaying results of the analyzing step,

including initializing the diagnostic procedure by comparing the breath with a known reference.

20. The method of claim 19 including sensing the expired breath with multiple sensors, thereby providing multiple characteristics of the expired breath to minimize false positives.

21. A device for detecting a substance in a patient'"'"'s expired breath indicative of cardiovascular distress, comprising:

a sample chamber to receive and contain the breath;

means for analyzing the breath contained within said sample chamber for the existence of the substance;

display means operatively coupled to said analyzing means to provide an output correlative to the existence of the substance;

means to initialize said device including reference means for receiving an exemplar having initializing qualities;

said reference means coupled to said analyzing means;

comparing means coupled to said analyzing means to receive data therefrom whereby said device will have been initialized;

said analyzing means including plural sensors, each said sensor tuned to a different characteristic of the substance to render less likely a false positive reading; and

means to sense the initiation of said detector including a flow meter coupled both to said sample chamber and a central processor control unit whereby said device is enabled when breath expired by the patient triggers said flow meter to actuate said central processor control unit.

22. A device for detecting a substance in a patient'"'"'s expired breath indicative of cardiovascular distress, comprising:

a sample chamber to receive and contain the breath;

means for analyzing the breath contained within said sample chamber for the existence of the substance;

display means operatively coupled to said analyzing means to provide an output correlative to the existence of the substance;

means to initialize said detector; and

means to sense the initiation of said detector including a flow meter coupled both to said sample chamber and a central processor control unit, whereby said device is enabled when breath expired by the patient triggers said flow meter to actuate said central processor control unit.

23. A method for determining the concentration of adenosine in a patient'"'"'s expired breath indicative of cardiovascular distress, the steps including:

containing a sample of expired breath from the patient;

shining a light through the sample of expired breath;

detecting and recording the light intensity before it has passed through the sample of expired breath;

detecting and recording the light intensity after it has passed through the sample of expired breath;

calculating the concentration of adenosine by utilizing the formula;

##EQU3## where C is the concentration of adenosine, I_O is the light intensity before the light has passed through the sample of expired breath,

I_F is the light intensity after the light has passed through the sample of expired breath,

a is the absorption constant, and

b is the absorption path length.