Dermatological glutathione alkyl ester composition and a process for topical treatment

• US 5,516,507 A
• Filed: 05/04/1994
• Issued: 05/14/1996
• Est. Priority Date: 05/07/1993
• Status: Expired due to Fees

• Current Assignee: L'Oreal SA
• Original Assignee: L'Oreal SA
• Inventors: Lindenbaum, Albert, Loufrani, Catherine, Junino, Alex, Colin, Christian, N'Guyen, Quang L.
• Primary Examiner(s): Dodson, Shelley A.
• Application Number:
  US08/237,924
• Time in Patent Office: 741 Days
• Field of Search: 514/844, 424/59, 424/60
• US Class Current: 424/59
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61K 8/66 Enzymes
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: A61Q 7/00 Preparations for affecting hair growth
• CPC Class Codes: Y10S 977/904 for medical, immunological, body treatment, or diagnosis
• CPC Class Codes: Y10S 977/926 Topical chemical, e.g. cosmetic or sunscreen

Abstract

A process for topical treatment of cutaneous ageing involves applying to skin a cosmetic or dermatological composition containing, as an active ingredient, a glutathione alkyl ester. The glutathione alkyl ester corresponds to the formula: ##STR1## in which R represents an alkyl radical having from 1 to 10 carbon atoms.

Claims

1. A process for the topical treatment of cutaneous ageing which comprises applying to the part of the skin to be treated an effective amount of a composition containing as active ingredient from 0.01 to 10% by weight relative to the total weight of the composition of a glutathione monoalkyl ester corresponding to the formula:

##STR7## in which;

R represents an alkyl radical having from 1 to 10 carbon atoms.

2. The process of claim 1, wherein said glutathione monoalkyl ester is glutathione monomethyl ester, monoethyl ester or monooctyl ester.

3. The process of claim 1 wherein said glutathione monoalkyl ester is present in the composition at a concentration of between 0.01% and 10% by weight relative to the total weight of the composition.

4. The process of claim 1, wherein said composition further contains an active ingredient selected from the group consisting of a superoxide dismutase of animal, human or plant origin, a superoxide dismutase grafter with polyalkylene oxide, polyethylene glycol, polysaccharide or acylated groups, a superoxide dismutase stabilized with phosphate and copper 3'"'"', 5'"'"'-diisopropyl salicylate.

5. The process of claim 4, wherein said active ingredient is present at a concentration of between 0.001 and 10% by weight relative to the total weight of the composition.

6. The process of claim 1 wherein said composition further comprises, at least one metal chelating agent.

7. The process of claim 1 wherein said composition further comprises metallic oxide pigments.

8. The process of claim 7, wherein said pigments are present in the composition at a concentration of between 0.1 and 15% by weight relative to the total weight of the composition.

9. A composition for the topical treatment of cutaneous ageing, comprising, in a suitable carrier for skin application, an effective amount of a glutathione mono-alkyl ester corresponding to the formula:

##STR8## in which;

R represents an alkyl radical having 1 to 10 carbon atoms,

said composition further comprising an active ingredient selected from the group consisting of a superoxide dismutase of animal, human or plant origin, a superoxide dismutase grafted with polyalkylene oxide, polyethylene glycol, polysaccharide or acylated groups, a superoxide dismutase stabilized with phosphate and copper 3'"'"', 5═

-diisopropyl salicylate.

10. The composition of claim 9, wherein said glutathione mono-alkyl ester is present in a proportion of between 0.1 and 10% and said active ingredient in a proportion of between 0.001 and 10% by weight relative to the total weight of the composition.