Dispensing device powered by hydrogel

• US 5,516,527 A
• Filed: 10/09/1992
• Issued: 05/14/1996
• Est. Priority Date: 01/12/1989
• Status: Expired due to Fees

• Current Assignee: Pfizer Inc.
• Original Assignee: Pfizer Inc.
• Inventors: Curatolo, William J.
• Primary Examiner(s): Venkat, Jyothsan
• Application Number:
  US07/960,186
• Time in Patent Office: 1,313 Days
• Field of Search: 424/451, 424/461, 424/462, 424/464, 424/413, 424/480, 424/482
• US Class Current: 424/461
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

This invention relates to devices useful for the controlled delivery of one or more beneficial agents to an environment of use. More specifically, this invention concerns such devices which are powered by hydrogel. This invention also relates to the controlled delivery of one or more beneficial agents to an aqueous environment of use through the use of such hydrogel powered dispensing devices. Also disclosed are methods for the controlled delivery of one or more beneficial agents to an aqueous environment of use which comprises administering to or otherwise placing the devices of this invention in the environment of use.

Claims

1. A dispensing device for releasing a drug to an external environment which comprises:

a capsule containing a plurality of dispensing devices, each dispensing device comprising

(a) an innermost hydrogel layer, said innermost hydrogel layer not including drug;

(b) a second layer, said second layer surrounding said innermost layer and said second layer comprising a mixture comprising one or more drugs and from about 50 to about 95 weight percent hydrogel, said hydrogel in said second layer being different from said hydrogel in said first layer; and

(c) a porous coating which surrounds the mixture, said mixture in communication through said pores with the external environment, and said pores having a pore size sufficient to allow passage of the drugs through to the external environment

wherein the rate of drug release is relatively independent of the solubility of the drug.

2. The dispensing device according to claim 1 wherein the beneficial agent is a water insoluble drug.

3. The dispensing device according to claim 2 wherein the hydrogel is polyethylene oxide.

4. The dispensing device according to claim 3 wherein the coating comprises cellulose acetate.

5. The dispensing device according to claim 1 wherein the mixture additionally comprises an osmotically effective solute.

6. The dispensing device according to claim 2 wherein the pores have a diameter greater than the particle size of the water insoluble drug.

7. The dispensing device according to claim 4 wherein the coating additionally contains at least one hole.

8. A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 1 into the environment of use.

9. The device as recited in claim 1 wherein the mixture comprises at least two drugs and the rate of drug release is relatively independent of the solubility of the drugs.

10. The device as recited in claim 1 wherein said device excludes a semi-permeable coating.