Cardiac blood flow sensor and method

• US 5,520,190 A
• Filed: 10/31/1994
• Issued: 05/28/1996
• Est. Priority Date: 10/31/1994
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Ventritex Incorporated (Abbott Laboratories Incorporated)
• Inventors: Fayram, Timothy A., Benedict, George J.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US08/331,416
• Time in Patent Office: 575 Days
• Field of Search: 607/6, 607/17, 607/18, 607/21, 128/700, 128/713, 128/634, 374/131
• US Class Current: 600/513
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: G01F 1/6884 making use of temperature dependence of optical properties
• CPC Class Codes: G01K 11/3213 using changes in luminescence, e.g. at the distal end of the fibres
• CPC Class Codes: G01P 5/10 by measuring thermal variables

Abstract

A cardiac blood flow sensor includes a light source and a photodetector within a housing. The light source projects a beam through a fiber optic line having a first end optically connected to the housing and a distal tip positioned within the patient'"'"'s heart. A ruby positioned at the distal tip is heated by the beam, and fluoresces for a period of time after illumination ceases. The period of time depends on the temperature of the ruby, so that the fluorescent light is transmitted back through the optic line to the photodetector. The signal generated by the photodetector may be analyzed to estimate the blood flow rate, due to the thermal effect of blood flowing past the heated ruby. The flow sensor may be contained in a common housing with a defibrillator that is implanted in a patient. The sensor may remain inactive until a tachycardia or rapid heart rate is detected, upon which the light source is activated. The cardiac condition is analyzed based on the detected heart rate and blood flow and, if needed, an appropriate therapy is delivered.

Claims

1. A method for discrimination between a pathologic tachycardia and a physiologic tachycardia in a patient comprising the steps of:

selecting a predetermined threshold indicative of tachycardia;

detecting the patient'"'"'s heart rate;

comparing said detected heart rate with said predetermined threshold;

in response to detection of a heart rate above said predetermined threshold, illuminating a temperature sensitive element positioned within the patient'"'"'s blood stream, then sensing the duration of fluorescent light emitted;

heating the temperature sensitive element;

waiting a predetermined period of time following said heating step;

after said predetermined period following the heating of the temperature sensitive element, illuminating the temperature sensitive element and then sensing the duration of fluorescent light emitted to measure the temperature of the temperature sensitive element to obtain a relative measure of blood flow; and

determining whether the tachycardia is physiologic or pathologic in origin based on the relative measure of blood flow.

2. The method of claim 1 wherein the step of heating the temperature sensitive element includes projecting light onto the temperature sensitive element.

3. The method of claim 1 wherein the step of measuring the temperature of the temperature sensitive element includes sensing fluorescent light emitted from the temperature sensitive element.

4. The method of claim 1 including the step of comparing emissions of fluorescent light from the temperature sensitive element before and after the heating step.

5. The method of claim 1 including the step of applying electrical therapy to the patient'"'"'s heart in response to detection of a pathologic tachycardia.

6. An implantable cardiac therapy apparatus comprising:

a housing having a port for transmitting light between the housing interior and exterior;

a light source within the housing and in optical communication with the port, such that at least a portion of light emitted by the light source is transmitted along a first beam path between the light source and the port;

a photodetector having an electrical output, the photodetector being responsive to the intensity of light impinging thereon, the photodetector being positioned within the housing and in optical communication with the port, such that at least a portion of light entering the port is transmitted along a second beam path between the port and the detector to impinge on the photodetector;

a processor connected to the photodetector'"'"'s electrical output;

a flexible elongated light conduit having a first end optically connected to the housing port, and a distal tip including a temperature sensitive element, such that light from the light source is transmitted through the conduit to the distal tip, and such that at least a portion of any light generated by the distal tip is transmitted to the photodetector to generate a signal;

means for illuminating the temperature sensitive element before heating the temperature sensitive element, then sensing the duration of fluorescent light emitted;

means for waiting a predetermined time after heating the temperature sensitive element, then illuminating the temperature sensitive element and sensing the duration of fluorescent light emitted; and

a pulse generator having an input connected to the processor for generating an electric pulse in a lead extending from an output port of the pulse generator.

7. The apparatus of claim 6 wherein the pulse generator is an implantable cardioverter/defibrillator.

8. The apparatus of claim 6 wherein the pulse generator is contained within the housing.

9. The apparatus of claim 6 wherein the temperature sensitive element emits light in proportion to its temperature after excitation with electromagnetic radiation.

10. The apparatus of claim 6 wherein the conduit comprises a fiber optic line.

11. The apparatus of claim 6 wherein at least a portion of the conduit is enclosed by a biocompatible sheath.

12. The apparatus of claim 6 wherein the processor includes means for calculating a blood flow rate.

13. The apparatus of claim 6 including a dichroic beam splitter within the housing and within the first and second beam paths, such that portions of the beam paths are coextensive with each other between the beam splitter and the port, and are separate from each other adjacent the respective light source and photodetector.

14. The apparatus of claim 6 including a heart rate sensor.

15. A method of measuring blood flow in the blood stream of a patient, the method comprising the steps:

determining a first baseline temperature by illuminating a light-emitting temperature sensitive element within the blood stream through a flexible conduit having a distal tip immersed in the patient'"'"'s blood stream and analyzing light emitted therefrom;

heating the light-emitting temperature sensitive element;

waiting a predetermined time after heating the light-emitting temperature sensitive element;

determining a second temperature by illuminating a light-emitting temperature sensitive element and analyzing light emitted therefrom; and

analyzing the temperature change to determine the blood flow rate.

16. The method of claim 15 wherein the step of projecting the light includes stimulating fluorescence of the temperature sensitive element.

17. The method of claim 15 wherein the step of projecting the light includes projecting the light within the patient'"'"'s heart.

18. The method of claim 15 including the step of detecting the patient'"'"'s heart rate.

19. The method of claim 18 wherein the step of generating the light occurs in response to a detected heart rate above a preselected rate.